Evidence map›Paper›PMID 29790735›Full record

ReviewACS chemical biology2018

Sensing DNA through DNA Charge Transport.

Theodore J Zwang, Edmund C M Tse, Jacqueline K Barton

Abstract readReview
In one paragraph

Review in ACS chemical biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Modular DNA origami-based electrochemical detection of DNA and proteins.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Telomere Length Regulation.Frontiers in oncology · 2022
    Review
  9. Article
  10. Article
  11. Towards the Idea of Molecular Brains.International journal of molecular sciences · 2021
    Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. The Dynamics of Hole Transfer in DNA.Molecules (Basel, Switzerland) · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Theodore J ZwangDivision of Chemistry and Chemical Engineering , California Institute of Technology , Pasadena , California 91125 , United States.
Edmund C M TseDivision of Chemistry and Chemical Engineering , California Institute of Technology , Pasadena , California 91125 , United States.ORCID 0000-0002-9313-1290
Jacqueline K BartonDivision of Chemistry and Chemical Engineering , California Institute of Technology , Pasadena , California 91125 , United States.ORCID 0000-0001-9883-1600

Funding

ELECTROCHEMICAL DNA-BASED SENSORSR01GM061077 · NIGMS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI BARTON, JACQUELINE K · 2000 to 2017
$5.2M
NIGMS NIH HHS R01 GM061077
6 · The paper itself

Abstract

DNA charge transport chemistry involves the migration of charge over long molecular distances through the aromatic base pair stack within the DNA helix. This migration depends upon the intimate coupling of bases stacked one with another, and hence any perturbation in that stacking, through base modifications or protein binding, can be sensed electrically. In this review, we describe the many ways DNA charge transport chemistry has been utilized to sense changes in DNA, including the presence of lesions, mismatches, DNA-binding proteins, protein activity, and even reactions under weak magnetic fields. Charge transport chemistry is remarkable in its ability to sense the integrity of DNA.

Indexed as

ElectronsBase Pair MismatchDNADNA-Binding ProteinsElectrochemical TechniquesIntercalating AgentsMagnetic PhenomenaNucleic Acid ConformationProtein BindingStatic ElectricityDNADNA-Binding ProteinsIntercalating Agents

Identifiers

PMID29790735
PMCPMC6080280

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.