Evidence map›Paper›PMID 29790649›Full record

ReviewChemistry, an Asian journal2018

Hyperpolarized NMR Spectroscopy: d-DNP, PHIP, and SABRE Techniques.

Kirill V Kovtunov, Ekaterina V Pokochueva, Oleg G Salnikov, Samuel F Cousin, Dennis Kurzbach, Basile Vuichoud, Sami Jannin, Eduard Y Chekmenev, Boyd M Goodson, Danila A Barskiy and 1 more

Abstract readReview
In one paragraph

Review in Chemistry, an Asian journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 123 papers.

0numbers the graph read from it
0cells of the map it votes in
123citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

123 citing papers in PubMed.

  1. Article
  2. Hyperpolarization of PyridineAngewandte Chemie (International ed. in English) · 2026
    Article
  3. Article
  4. Over four minutes of pyruvate TNature communications · 2026
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Hyperpolarized NMR Reveals Low-Populated Folding Intermediates in DNA.Journal of the American Chemical Society · 2025
    Article
  11. Multidimensional pH-Temperature Mapping of SABRE-SHEATHThe journal of physical chemistry. B · 2025
    Article
  12. The journal of physical chemistry. B · 2025
    Article
  13. Article
  14. Article
  15. EfficientJournal of magnetic resonance open · 2025
    Article
  16. SABRE-SHEATH hyperpolarizedChemical communications (Cambridge, England) · 2025
    Article
  17. Parahydrogen-Hyperpolarized Propane-The journal of physical chemistry. A · 2025
    Article
  18. Review
  19. Review
  20. Article

63 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kirill V KovtunovLaboratory of Magnetic Resonance Microimaging, International Tomography Center, Siberian Branch of Russian Academy of Sciences (SB RAS), 3A Institutskaya St., Novosibirsk, 630090, Russia.ORCID http://orcid.org/0000-0001-7577-9619
Ekaterina V PokochuevaLaboratory of Magnetic Resonance Microimaging, International Tomography Center, Siberian Branch of Russian Academy of Sciences (SB RAS), 3A Institutskaya St., Novosibirsk, 630090, Russia.
Oleg G SalnikovLaboratory of Magnetic Resonance Microimaging, International Tomography Center, Siberian Branch of Russian Academy of Sciences (SB RAS), 3A Institutskaya St., Novosibirsk, 630090, Russia.
Samuel F CousinUniversité de Lyon, CNRS, Université Claude Bernard Lyon 1, École normale supérieure de Lyon (ENS de Lyon), Institut des Sciences Analytiques, UMR 5280, 5 rue de la Doua, 69100, Villeurbanne, France.
Dennis KurzbachLaboratoire des biomolécules, LBM, Département de chimie, École normale supérieure, PSL University, Sorbonne Université, CNRS, 75005, Paris, France.
Basile VuichoudUniversité de Lyon, CNRS, Université Claude Bernard Lyon 1, École normale supérieure de Lyon (ENS de Lyon), Institut des Sciences Analytiques, UMR 5280, 5 rue de la Doua, 69100, Villeurbanne, France.
Sami JanninUniversité de Lyon, CNRS, Université Claude Bernard Lyon 1, École normale supérieure de Lyon (ENS de Lyon), Institut des Sciences Analytiques, UMR 5280, 5 rue de la Doua, 69100, Villeurbanne, France.
Eduard Y ChekmenevDepartment of Chemistry, Integrative Biosciences (Ibio) and, Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI, 48202, United States.ORCID http://orcid.org/0000-0002-8745-8801
Boyd M GoodsonDepartment of Chemistry & Biochemistry, Materials Technology Center, Southern Illinois University, Carbondale, IL, 62901, United States.
Danila A BarskiyDepartment of Chemistry, University of California at Berkeley, Berkeley, CA, 94720-3220, United States.ORCID http://orcid.org/0000-0002-2819-7584
Igor V KoptyugLaboratory of Magnetic Resonance Microimaging, International Tomography Center, Siberian Branch of Russian Academy of Sciences (SB RAS), 3A Institutskaya St., Novosibirsk, 630090, Russia.

Funding

Physical Dynamics of Cancer Response to Chemotherapy in 3D MicroenvironmentsU01CA202229 · NCI · VANDERBILT UNIVERSITY · PI MARKOV, DMITRY, MCCAWLEY, LISA JOY · 2015 to 2019
$3.0M
Pure parahydrogen-enhanced metabolic MRI contrast agents for molecular imagingR21EB020323 · NIBIB · SOUTHERN ILLINOIS UNIVERSITY CARBONDALE · PI CHEKMENEV, EDUARD, GOODSON, BOYD M · 2015 to 2016
$416k
Magnetic Resonance Spectroscopy and Molecular Imaging of Metabolic Pathways in CancerR21CA220137 · NCI · WAYNE STATE UNIVERSITY · PI CHEKMENEV, EDUARD · 2017 to 2019
$390k
NCI NIH HHS R21 CA220137NCI NIH HHS U01 CA202229NIBIB NIH HHS R21 EB020323
6 · The paper itself

Abstract

The intensity of NMR signals can be enhanced by several orders of magnitude by using various techniques for the hyperpolarization of different molecules. Such approaches can overcome the main sensitivity challenges facing modern NMR/magnetic resonance imaging (MRI) techniques, whilst hyperpolarized fluids can also be used in a variety of applications in material science and biomedicine. This Focus Review considers the fundamentals of the preparation of hyperpolarized liquids and gases by using dissolution dynamic nuclear polarization (d-DNP) and parahydrogen-based techniques, such as signal amplification by reversible exchange (SABRE) and parahydrogen-induced polarization (PHIP), in both heterogeneous and homogeneous processes. The various new aspects in the formation and utilization of hyperpolarized fluids, along with the possibility of observing NMR signal enhancement, are described.

Indexed as

biological activitycontrast agentshyperpolarizationimaging agentsNMR spectroscopy

Identifiers

PMID29790649
PMCPMC6251772

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.