ArticlePlant, cell & environment2018
The intracellular nucleotide-binding leucine-rich repeat receptor (SlNRC4a) enhances immune signalling elicited by extracellular perception.
Article in Plant, cell & environment, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- Mechanisms and balanced regulation of plant immunity.Nature reviews. Molecular cell biology · 2026Review
- Plant immune co-receptors: bridging gaps toward next-generation crop defense.Stress biology · 2026Review
- Use of CRISPR Technology in Gene Editing for Tolerance to Biotic Factors in Plants: A Systematic Review.Current issues in molecular biology · 2024Review
- The maize ZmVPS23-like protein relocates the nucleotide-binding leucine-rich repeat protein Rp1-D21 to endosomes and suppresses the defense response.The Plant cell · 2023Article
- Dynamin-Related Proteins Enhance Tomato Immunity by Mediating Pattern Recognition Receptor Trafficking.Membranes · 2022Article
- Multilevel evolution shapes the function of NB-LRR encoding genes in plant innate immunity.Frontiers in plant science · 2022Review
- Method for the Production and Purification of Plant Immuno-Active Xylanase fromInternational journal of molecular sciences · 2021Article
- Cytokinin response induces immunity and fungal pathogen resistance, and modulates trafficking of the PRR LeEIX2 in tomato.Molecular plant pathology · 2020Article
- Diversity, Function and Regulation of Cell Surface and Intracellular Immune Receptors inPlants (Basel, Switzerland) · 2020Review
- Plant NLRs: The Whistleblowers of Plant Immunity.Plant communications · 2020Review
- The rice NLR pair Pikp-1/Pikp-2 initiates cell death through receptor cooperation rather than negative regulation.PloS one · 2020Article
- Article
- Proteomics of PTI and Two ETI Immune Reactions in Potato Leaves.International journal of molecular sciences · 2019Article
- Tomato Dynamin Related Protein 2A Associates With LeEIX2 and Enhances PRR Mediated Defense by Modulating Receptor Trafficking.Frontiers in plant science · 2019Article
- Uncoiling CNLs: Structure/Function Approaches to Understanding CC Domain Function in Plant NLRs.Plant & cell physiology · 2018Review
- NRC proteins - a critical node for pattern and effector mediated signaling.Plant signaling & behavior · 2018Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Plant recognition and defence against pathogens employs a two-tiered perception system. Surface-localized pattern recognition receptors (PRRs) act to recognize microbial features, whereas intracellular nucleotide-binding leucine-rich repeat receptors (NLRs) directly or indirectly recognize pathogen effectors inside host cells. Employing the tomato PRR LeEIX2/EIX model system, we explored the molecular mechanism of signalling pathways. We identified an NLR that can associate with LeEIX2, termed SlNRC4a (NB-LRR required for hypersensitive response-associated cell death-4). Co-immunoprecipitation demonstrates that SlNRC4a is able to associate with different PRRs. Physiological assays with specific elicitors revealed that SlNRC4a generally alters PRR-mediated responses. SlNRC4a overexpression enhances defence responses, whereas silencing SlNRC4 reduces plant immunity. Moreover, the coiled-coil domain of SlNRC4a is able to associate with LeEIX2 and is sufficient to enhance responses upon EIX perception. On the basis of these findings, we propose that SlNRC4a acts as a noncanonical positive regulator of immunity mediated by diverse PRRs. Thus, SlNRC4a could link both intracellular and extracellular immune perceptions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.