ArticleNanoscale2018
Deciphering ion concentration polarization-based electrokinetic molecular concentration at the micro-nanofluidic interface: theoretical limits and scaling laws.
Article in Nanoscale, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Impact of Salt and Urine Matrices on Electrokinetic Stacking Coupled to Paper Spray Mass Spectrometry.Journal of the American Society for Mass Spectrometry · 2026Article
- Accelerating Cleavage Activity of CRISPR-Cas13 System on a Microfluidic Chip for Rapid Detection of RNA.Analytical chemistry · 2025Article
- Electrokinetic and Electroconvective Effects in Ternary Electrolyte Near Ion-Selective Microsphere.Membranes · 2023Article
- Continuous Submicron Particle Separation Via Vortex-Enhanced Ionic Concentration Polarization: A Numerical Investigation.Micromachines · 2022Article
- Numerical Simulation of Continuous Extraction of LiMembranes · 2021Article
- Simulation and Experimental Study of Ion Concentration Polarization Induced Electroconvective Vortex and Particle Movement.Micromachines · 2021Article
- Overlimiting current near a nanochannel a new insight using molecular dynamics simulations.Scientific reports · 2021Article
- One-Step Nucleic Acid Purification and Noise-Resistant Polymerase Chain Reaction by Electrokinetic Concentration for Ultralow-Abundance Nucleic Acid Detection.Angewandte Chemie (International ed. in English) · 2020Article
- Free Flow Ion Concentration Polarization Focusing (FF-ICPF).Analytical chemistry · 2020Article
- Electroosmotic Flow Behavior of Viscoelastic LPTT Fluid in a Microchannel.Micromachines · 2019Article
- Universal amplification-free molecular diagnostics by billion-fold hierarchical nanofluidic concentration.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Nanoelectrokinetic bufferchannel-less radial preconcentrator and online extractor by tunable ion depletion layer.Biomicrofluidics · 2019Article
- Article
- Pressure-Modulated Selective Electrokinetic Trapping for Direct Enrichment, Purification, and Detection of Nucleic Acids in Human Serum.Analytical chemistry · 2018Article
- Direct numerical simulation of continuous lithium extraction from high MgJournal of membrane science · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The electrokinetic molecular concentration (EMC) effect at the micro-nanofluidic interface, which enables million-fold preconcentration of biomolecules, is one of the most compelling yet least understood nanofluidic phenomena. Despite the tremendous interests in EMC and the substantial efforts devoted, the detailed mechanism of EMC remains an enigma so far owing to its high complexity, which gives rise to the significant scientific controversies outstanding for over a decade and leaves the precise engineering of EMC devices infeasible. We report a series of experimental and theoretical new findings that decipher the mechanism of EMC. We demonstrate the first elucidation of two separate operating regimes of EMC, and establish the first theoretical model that analytically yet concisely describes the system. We further unveil the dramatically different scaling behaviors of EMC in the two regimes, thereby clarifying the long-lasting controversies. We believe this work represents important progress towards the scientific understanding of EMC and related nano-electrokinetic systems, and would enable the rational design and optimization of EMC devices for a variety of applications.
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Registered trials
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