ArticlePharmacogenomics2018
Multi-ethnic SULT1A1 copy number profiling with multiplex ligation-dependent probe amplification.
Article in Pharmacogenomics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The trial behind it
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Who cites it
11 citing papers in PubMed.
- Genetic Variation inJournal of personalized medicine · 2026Article
- The evolving landscape of pharmacogenomics: Current achievements and future directions.Pharmacological reviews · 2026Review
- Article
- Sulphotransferase-mediated toxification of chemicals in mouse models: effect of knockout or humanisation of SULT genes.Essays in biochemistry · 2024Review
- Structural variation of the coding and non-coding human pharmacogenome.NPJ genomic medicine · 2023Article
- Copy number variations of cytochromeAsian biomedicine : research, reviews and news · 2023Article
- Population Pharmacokinetics of Z-Endoxifen in Patients With Advanced Solid Tumors.Journal of clinical pharmacology · 2022Article
- Simple and Robust Detection ofPharmaceuticals (Basel, Switzerland) · 2022Article
- Combination of Genome-Wide Polymorphisms and Copy Number Variations of Pharmacogenes in Koreans.Journal of personalized medicine · 2021Article
- Structural variation at the CYP2C locus: Characterization of deletion and duplication alleles.Human mutation · 2019Article
- Sulfation pathways from red to green.The Journal of biological chemistry · 2019Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
aimTo develop a SULT1A1 multiplex ligation-dependent probe amplification assay and to investigate multi-ethnic copy number variant frequencies.
methodsA novel multiplex ligation-dependent probe amplification assay was developed and tested on 472 African-American, Asian, Caucasian, Hispanic and Ashkenazi Jewish individuals.
resultsThe frequencies of atypical total copy number (i.e., greater or less than two) were 38.7% for Hispanics, 38.9% for Ashkenazi Jewish, 43.2% for Caucasians, 53.6% for Asians and 64.1% for African-Americans. Heterozygous SULT1A1 deletion carriers (slow sulfators) were most common among Caucasians (8.4%), whereas African-Americans had the highest frequencies of three or more copies (rapid sulfators; 60.9%).
conclusionDifferent ethnic and racial populations have varying degrees of SULT1A1-mediated sulfation activity, which warrants further research and that may have utility for drug response prediction among SULT1A1-metabolized medications.
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Registered trials
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