Evidence map›Paper›PMID 29790379›Full record

ArticleAntioxidants & redox signaling2019

A Review of Hydrogen Sulfide Synthesis, Metabolism, and Measurement: Is Modulation of Hydrogen Sulfide a Novel Therapeutic for Cancer?

Xu Cao, Lei Ding, Zhi-Zhong Xie, Yong Yang, Matthew Whiteman, Philip K Moore, Jin-Song Bian

Open access · hybridAbstract read
In one paragraph

Article in Antioxidants & redox signaling, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 175 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
175citing papers in PubMed, 1 pooled it
20.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

175 citing papers in PubMed, 1 synthesis or guideline pooled it, 402 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
  6. HCellular & molecular biology letters · 2026
    Article
  7. Article
  8. Review
  9. Article
  10. Hydrogen Sulfide Metabolism in the Skin: From Physiology to Malignancy.International journal of molecular sciences · 2025
    Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article

115 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Xu Cao1 Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Lei Ding1 Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Zhi-Zhong Xie2 Institute of Pharmacy and Pharmacology, University of South China, Hengyang, China.
Yong Yang1 Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Matthew Whiteman4 University of Exeter Medical School, Exeter, United Kingdom.
Philip K Moore1 Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Jin-Song Bian1 Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
National University of Singapore · SGChina Pharmaceutical University · CNUniversity of Exeter · GBUniversity of South China · CN

Funding

Medical Research Council MC_PC_15047Medical Research Council MR/M022706/1
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsBiosynthetic PathwaysCell SurvivalCystathionine beta-SynthaseCystathionine gamma-LyaseEnzyme InhibitorsHumansHydrogen SulfideMiceNeoplasmsSulfurtransferasesCystathionine beta-SynthaseCystathionine gamma-LyaseEnzyme InhibitorsHydrogen SulfideSulfurtransferasescancer biologycancer treatmentCBS inhibitorsHS donorsHS-releasing hybridshydrogen sulfide

Identifiers

PMID29790379
PMCPMC6551999
OpenAlexW2803997671

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.