ArticleAnalytical chemistry2018
Development of an Electrochemical Paper-Based Analytical Device for Trace Detection of Virus Particles.
Article in Analytical chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Electronic and electrochemical viral detection for point-of-care use: A systematic review.PloS one · 2021Pooled it
- Paper as a Sustainable Material for Smart Electrochemical (Bio)sensors with Unprecedented Features: A Perspective.Analytical chemistry · 2025Review
- Complementary cost-effective electrochemical platforms for point-of-use biosensing.Advanced sensor research · 2025Article
- Article
- Biosensors for the detection of flaviviruses: A review.Synthetic and systems biotechnology · 2025Review
- CRISPR/Cas14 and G-Quadruplex DNAzyme-Driven Biosensor for Paper-Based Colorimetric Detection of African Swine Fever Virus.ACS sensors · 2024Article
- Insights into the Fabrication and Electrochemical Aspects of Paper Microfluidics-Based Biosensor Module.Biosensors · 2023Review
- Paper-based electrochemical biosensors for the diagnosis of viral diseases.Mikrochimica acta · 2023Review
- Recent advances in gold electrode fabrication for low-resource setting biosensing.Lab on a chip · 2023Review
- Biosensors for the detection of disease outbreaks through wastewater-based epidemiology.Trends in analytical chemistry : TRAC · 2022Review
- Emerging Bioanalytical Devices and Platforms for Rapid Detection of Pathogens in Environmental Samples.Micromachines · 2022Review
- Label-free electrochemical microfluidic biosensors: futuristic point-of-care analytical devices for monitoring diseases.Mikrochimica acta · 2022Review
- A Customized Microfluidic Paper-Based Platform for Colorimetric Immunosensing: Demonstrated via hCG Assay for Pregnancy Test.Biosensors · 2021Article
- Synthesis and grafting of diazonium tosylates for thermoplastic electrode immunosensors.Analytical methods : advancing methods and applications · 2021Article
- Electrochemical diagnostics of infectious viral diseases: Trends and challenges.Biosensors & bioelectronics · 2021Review
- Review
- Recent advances in sensitive surface-enhanced Raman scattering-based lateral flow assay platforms for point-of-care diagnostics of infectious diseases.Sensors and actuators. B, Chemical · 2021Article
- Paper-Based Point-of-Care Testing of SARS-CoV-2.Frontiers in bioengineering and biotechnology · 2021Review
- Label-Free Electrochemical Biosensors for the Determination ofSensors (Basel, Switzerland) · 2020Review
- Screen-Printed Electrodes: Promising Paper and Wearable Transducers for (Bio)Sensing.Biosensors · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Viral pathogens are a serious health threat around the world, particularly in resource limited settings, where current sensing approaches are often insufficient and slow, compounding the spread and burden of these pathogens. Here, we describe a label-free, point-of-care approach toward detection of virus particles, based on a microfluidic paper-based analytical device with integrated microwire Au electrodes. The device is initially characterized through capturing of streptavidin modified nanoparticles by biotin-modified microwires. An order of magnitude improvement in detection limits is achieved through use of a microfluidic device over a classical static paper-based device, due to enhanced mass transport and capturing of particles on the modified electrodes. Electrochemical impedance spectroscopy detection of West Nile virus particles was carried out using antibody functionalized Au microwires, achieving a detection limit of 10.2 particles in 50 μL of cell culture media. No increase in signal is found on addition of an excess of a nonspecific target (Sindbis). This detection motif is significantly cheaper (∼$1 per test) and faster (∼30 min) than current methods, while achieving the desired selectivity and sensitivity. This sensing motif represents a general platform for trace detection of a wide range of biological pathogens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.