Evidence map›Paper›PMID 29790271›Full record

SynthesisBJOG : an international journal of obstetrics and gynaecology2018

Correlation between neonatal outcomes of twins depends on the outcome: secondary analysis of twelve randomised controlled trials.

L N Yelland, E Schuit, J Zamora, P F Middleton, A C Lim, A H Nassar, L Rode, V Serra, E A Thom, C Vayssière and 2 more

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BJOG : an international journal of obstetrics and gynaecology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Effects of tocolysis with nifedipine or atosiban on child outcome: follow-up of the APOSTEL III trial.BJOG : an international journal of obstetrics and gynaecology · 2020
    Trial
  5. Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

L N YellandSouth Australian Health and Medical Research Institute, Adelaide, SA, Australia.
E SchuitJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands.
J ZamoraWomen's Health Research Unit, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
P F MiddletonSouth Australian Health and Medical Research Institute, Adelaide, SA, Australia.
A C LimDepartment of Obstetrics & Gynecology and GROW-School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht, the Netherlands.
A H NassarDepartment of Obstetrics and Gynecology, American University of Beirut Medical Center, Beirut, Lebanon.
L RodeDepartment of Obstetrics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
V SerraMaternal-Fetal Medicine Unit, Valencia Infertility Institute, University of Valencia, Valencia, Spain.
E A ThomGeorge Washington University Biostatistics Center, Washington, DC, USA.
C VayssièreDepartment of Obstetrics and Gynecology, Paule de Viguier Hospital, CHU Toulouse, Toulouse, France.
Bwj MolDepartment of Obstetrics and Gynaecology, Monash Medical Centre, Monash Health and Monash University, Clayton, Vic., Australia.
S GatesWarwick Clinical Trials Unit, University of Warwick, Coventry, UK.

Funding

Data Coord Ctr-NICHD Cooperative Multicenter Maternal Medicine Units Research NetU10HD036801 · NICHD · GEORGE WASHINGTON UNIVERSITY · PI CLIFTON, REBECCA GERSNOVIEZ · 2009 to 2021
$174.2M
MATERNAL FETAL RESEARCH NETWORK: DATA COORDINATING CTRU01HD036801 · NICHD · GEORGE WASHINGTON UNIVERSITY · PI THOM, ELIZABETH ANN · 1998 to 2008
$27.0M
Australian National Health and Medical Research Council Early Career Fellowship 1052388NICHD NIH HHS U01 HD036801NICHD NIH HHS U10 HD036801Women's and Children's Hospital Foundation Research Project Grant
6 · The paper itself

Abstract

objectiveTo estimate the magnitude of the correlation between neonatal outcomes of twins and demonstrate how this information can be used in the design of randomised controlled trials (RCTs) in women with twin pregnancies.

designSecondary analysis of data from 12 RCTs.

settingObstetric care in multiple countries, 2004-2012. POPULATION OR SAMPLE: 4504 twin pairs born to women who participated in RCTs to assess treatments given during pregnancy.

methodsIntraclass correlation coefficients (ICCs) were estimated using log-binomial and linear models.

main outcome measuresPerinatal death, respiratory distress syndrome, bronchopulmonary dysplasia, intraventricular haemorrhage, necrotising enterocolitis, sepsis, neonatal intensive care unit admission, birthweight, low birthweight and two composite measures of adverse neonatal outcome.

resultsICCs for the composite measures of adverse neonatal outcome were all above 0.5, indicating moderate to strong correlation between adverse outcomes of twins. For individual neonatal outcomes, median ICCs across trials ranged from 0.13 to 0.79 depending on the outcome. An example illustrates how ICCs can be used in sample size calculations for RCTs in women with twin pregnancies.

conclusionsThe correlation between neonatal outcomes of twins varies considerably between outcomes and may be lower than expected. Our ICC estimates can be used for designing and analysing RCTs that recruit women with twin pregnancies and for performing meta-analyses that include such RCTs. Researchers are encouraged to report ICCs for neonatal outcomes in twins in their own RCTs. TWEETABLE ABSTRACT: Correlation between neonatal outcomes of twins depends on the outcome and may be lower than expected.

Indexed as

Pregnancy, TwinAdultCorrelation of DataFemaleGestational AgeHumansInfant, NewbornInfant, Newborn, DiseasesModels, StatisticalPerinatal DeathPregnancyPregnancy OutcomeRandomized Controlled Trials as TopicTwinsBayesian analysisintraclass correlation coefficientmeta-analysispowersample sizetwins

Identifiers

PMID29790271
PMCPMC8189665

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.