ArticleClinical journal of gastroenterology2018
A case of Jackhammer esophagus caused by eosinophilic esophagitis in which per-oral endoscopic myotomy resulted in symptom improvement.
Article in Clinical journal of gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Role of mechanoregulation in mast cell-mediated immune inflammation of the smooth muscle in the pathophysiology of esophageal motility disorders.American journal of physiology. Gastrointestinal and liver physiology · 2024Review
- Esophageal dysmotility in patients with eosinophilic esophagitis: pathogenesis, assessment tools, manometric characteristics, and clinical implications.Esophagus : official journal of the Japan Esophageal Society · 2023Review
- Clinical presentation and therapeutic outcome of patients with jackhammer esophagus-a multicenter cohort study in Japan.Esophagus : official journal of the Japan Esophageal Society · 2022Article
- Hypercontractile esophagus responsive to potassium-competitive acid blockers: a case report.BMC gastroenterology · 2022Article
- Pathophysiology of Dysphagia in Eosinophilic Esophagitis: Causes, Consequences, and Management.Digestive diseases and sciences · 2022Review
- Endoscopic Ultrasonography in Children with Eosinophilic Esophagitis-A Review.Pediatric reports · 2022Review
- Dysmotility in Eosinophilic Esophagitis.Frontiers in pediatrics · 2022Review
- Manometrically jackhammer esophagus with fluoroscopically/endoscopically distal esophageal spasm: a case report.BMC gastroenterology · 2021Article
- Symptom-based diagnostic approach for eosinophilic esophagitis.Journal of gastroenterology · 2020Review
- Markedly Effective Steroid Treatment of Three Patients with Allergy-related Jackhammer Esophagus.Internal medicine (Tokyo, Japan) · 2020Article
- Oesophageal eosinophilia and oesophageal diseases in children: are the limits clear?BMJ paediatrics open · 2020Review
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Authors and funding
12 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
A 73-year-old female with a 6-month history of progressive dysphagia and chest pain was referred to our hospital. She underwent esophagogastroduodenoscopy, which revealed abnormally strong contractions in the distal esophagus. Esophageal biopsy specimens showed massive eosinophil infiltration into the epithelium, and high-resolution manometry (HRM) also demonstrated abnormally strong contractions in the distal esophagus. Based on these results, she was diagnosed with Jackhammer esophagus (JHE) due to eosinophilic esophagitis (EoE). Treatment was started with 5 mg/day of prednisolone (PSL), and the number of peripheral blood eosinophils quickly decreased without any improvement in the patient's dysphagia. Esophageal biopsy specimens obtained after the PSL treatment showed the disappearance of eosinophils from the epithelium. However, abnormally strong contractions were still detected on HRM. Per-oral endoscopic myotomy (POEM) was performed to treat the JHE. Interestingly, the intraoperative esophageal muscle biopsy sample demonstrated massive eosinophil infiltration into the muscle layer. After the POEM, the patient's symptoms improved, and abnormal contractions were no longer detected on HRM. The current case suggests that when EoE combined with an esophageal motility disorder are refractory to steroid therapy, clinicians should be aware that motility disorders can develop due to eosinophil infiltration deep into the esophageal muscularis propria.
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