ReviewJournal of experimental orthopaedics2018
Orthopaedic regenerative tissue engineering en route to the holy grail: disequilibrium between the demand and the supply in the operating room.
Review in Journal of experimental orthopaedics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Long head of the biceps as a local autograft for surgical treatment of high-grade acromioclavicular dislocations: a clinical anatomy and feasibility study.JSES reviews, reports, and techniques · 2025Article
- Operative Treatment of Nonprimary Osteochondral Lesions of the Talus: A Systematic Review.Orthopaedic journal of sports medicine · 2024Review
- [Surgeons vs. scientists-Mind the gap! : Survey study on biomaterials for bone defects].Orthopadie (Heidelberg, Germany) · 2024Article
- Autologous platelet-rich plasma in the delayed union of long bone fractures - A quasi experimental study.Journal of orthopaedics · 2023Article
- Combining biomechanical stimulation and chronobiology: a novel approach for augmented chondrogenesis?Frontiers in bioengineering and biotechnology · 2023Review
- Advanced Gene Therapy Strategies for the Repair of ACL Injuries.International journal of molecular sciences · 2022Review
- Polycaprolactone-Based 3D-Printed Scaffolds as Potential Implant Materials for Tendon-Defect Repair.Journal of functional biomaterials · 2022Article
- Lineage Differentiation Potential of Different Sources of Mesenchymal Stem Cells for Osteoarthritis Knee.Pharmaceuticals (Basel, Switzerland) · 2022Review
- MUW researcher of the month.Wiener klinische Wochenschrift · 2020Article
- The Clinical Use of Biologics in the Knee Lesions: Does the Patient Benefit?Current reviews in musculoskeletal medicine · 2019Review
- Meniscal allograft transplants and new scaffolding techniques.EFORT open reviews · 2019Review
- Suturable regenerated silk fibroin scaffold reinforced with 3D-printed polycaprolactone mesh: biomechanical performance and subcutaneous implantation.Journal of materials science. Materials in medicine · 2019Article
- Preclinical safety study of a combined therapeutic bone wound dressing for osteoarticular regeneration.Nature communications · 2019Article
- Micro-CT - a digital 3D microstructural voyage into scaffolds: a systematic review of the reported methods and results.Biomaterials research · 2018Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Orthopaedic disorders are very frequent, globally found and often partially unresolved despite the substantial advances in science and medicine. Their surgical intervention is multifarious and the most favourable treatment is chosen by the orthopaedic surgeon on a case-by-case basis depending on a number of factors related with the patient and the lesion. Numerous regenerative tissue engineering strategies have been developed and studied extensively in laboratory through in vitro experiments and preclinical in vivo trials with various established animal models, while a small proportion of them reached the operating room. However, based on the available literature, the current strategies have not yet achieved to fully solve the clinical problems. Thus, the gold standards, if existing, remain unchanged in the clinics, notwithstanding the known limitations and drawbacks. Herein, the involvement of regenerative tissue engineering in the clinical orthopaedics is reviewed. The current challenges are indicated and discussed in order to describe the current disequilibrium between the needs and solutions made available in the operating room. Regenerative tissue engineering is a very dynamic field that has a high growth rate and a great openness and ability to incorporate new technologies with passion to edge towards the Holy Grail that is functional tissue regeneration. Thus, the future of clinical solutions making use of regenerative tissue engineering principles for the management of orthopaedic disorders is firmly supported by the clinical need.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.