Evidence map›Paper›PMID 29790036›Full record

ArticleThe international journal of cardiovascular imaging2018

Variability of native T1 values: implication for defining regional myocardial changes using MRI.

Kai Lin, Kenichiro Suwa, Heng Ma, Jeremy D Collins, Michael Markl, James C Carr

Abstract read
In one paragraph

Article in The international journal of cardiovascular imaging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Automated quantification of myocardial tissue characteristics from native TJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2020
    Article
  4. Cardiovascular imaging 2018 in the International Journal of Cardiovascular Imaging.The international journal of cardiovascular imaging · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kai LinDepartment of Radiology, Northwestern University, 737 N Michigan Avenue, Suite 1600, Chicago, IL, 60611, USA. kai-lin@northwestern.edu.ORCID http://orcid.org/0000-0002-0540-4077
Kenichiro SuwaDepartment of Radiology, Northwestern University, 737 N Michigan Avenue, Suite 1600, Chicago, IL, 60611, USA.
Heng MaDepartment of Radiology, Northwestern University, 737 N Michigan Avenue, Suite 1600, Chicago, IL, 60611, USA.
Jeremy D CollinsDepartment of Radiology, Northwestern University, 737 N Michigan Avenue, Suite 1600, Chicago, IL, 60611, USA.
Michael MarklDepartment of Radiology, Northwestern University, 737 N Michigan Avenue, Suite 1600, Chicago, IL, 60611, USA.
James C CarrDepartment of Radiology, Northwestern University, 737 N Michigan Avenue, Suite 1600, Chicago, IL, 60611, USA.

Funding

Comprehensive Cardiac Structure-Function Analysis in Heart TransplantationR01HL117888 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CARR, JAMES, MARKL, MICHAEL · 2014 to 2025
$6.4M
Quantitative MRI for the assessment of subclinical CAD in T2DMK01HL121162 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LIN, KAI · 2015 to 2019
$800k
Automatic quantification of myocardial motion in older adultsR03HL144891 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LIN, KAI · 2018 to 2019
$158k
NHLBI NIH HHS K01 HL121162NHLBI NIH HHS K01HL121162NHLBI NIH HHS R01 HL117888NHLBI NIH HHS R01HL117888NHLBI NIH HHS R03 HL144891
6 · The paper itself

Abstract

The aim of the present study was to establish T1 variation (T1v) thresholds for duplicated measurements of regional T1 values in left ventricle (LV) using magnetic resonance imaging (MRI). Eighteen healthy volunteers were recruited to undergo two consecutive cardiac MRI scans using modified Look-Locker Inversion recovery (MOLLI) with two spatial resolutions on different days to repeat T1 measurements on LV. The absolute differences (d) and standard deviations (SDs) of regional T1 values were acquired with the two scans and two readers. T1v threshold (mean difference + 2SD), intra-class correlation coefficient (ICC) and coefficient of variation (CoV) were calculated. T1 mapping using the MOLLI sequence (with multiple spatial resolutions) was successfully performed in all 18 volunteers twice. On a per-slice basis, ICCs for intra-observer, inter-observer, inter-resolution and inter-study T1v were 0.988, 0.899, 0.763 and 0.6. CoVs were 0.72, 2.39, 3.90 and 4.28%. T1v thresholds were 22, 66, 118 and 120 ms. On a per-segment basis, ICCs for intra-observer, inter-observer, inter-resolution and inter-study T1v were 0.974, 0.859, 0.711 and 0.594. CoVs were 1.09, 3.36, 4.69 and 5.01%. T1v thresholds were 33, 94, 140 and 144 ms. Those thresholds may be useful for discriminating disease-initiated T1v from random errors of T1 measurements.

Indexed as

AdultAgedFemaleHeartHumansMagnetic Resonance ImagingMaleMiddle AgedMyocardiumObserver VariationPredictive Value of TestsReproducibility of ResultsYoung AdultMOLLIMRIMyocardiumNative T1 variation

Identifiers

PMID29790036
PMCPMC6160321

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.