ArticleEuropean journal of trauma and emergency surgery : official publication of the European Trauma Society2019
The roles of early surgery and comorbid conditions on outcomes of severe necrotizing soft-tissue infections.
Article in European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Time is of the essence when treating necrotizing soft tissue infections: a systematic review and meta-analysis.World journal of emergency surgery : WJES · 2020Pooled it
- Severe necrotizing soft tissue infections (SENSEI) study: Protocol for a multi-centered audit.JPRAS open · 2026Article
- Comparison between vacuum sealing drainage (VSD) and conventional dressing for fournier's gangrene: a single-centre retrospective study.BMC surgery · 2025Article
- Article
- Time to diagnose and time to surgery in patients presenting with necrotizing fasciitis: a retrospective analysis.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025Article
- Is overweight a predictor for a more severe course of disease in cases of necrotizing fasciitis?European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2024Article
- Association between time to surgery and hospital mortality in patients with community-acquired limb necrotizing fasciitis: an 11-year multicenter retrospective cohort analysis.BMC infectious diseases · 2024Article
- Case report: A case of severe lower limb necrotizing fasciitis caused by an insulin injection has been reported.Frontiers in medicine · 2024Article
- The Etiology, Antibiotic Therapy and Outcomes of Bacteremic Skin and Soft-Tissue Infections in Onco-Hematological Patients.Antibiotics (Basel, Switzerland) · 2023Article
- Elderly Patients Managed Non-Operatively with Abscesses of the Anorectal Region Have Five Times Higher Rate of Mortality Compared to Non-Elderly.International journal of environmental research and public health · 2023Article
- Diagnostic and Prognostic Value of Laboratory Risk Indicator for Necrotizing Fasciitis Score.Cureus · 2023Article
- Article
- A case report of Actinomyces-associated vulvar necrotizing soft tissue infection: Aspects of multidisciplinary care.International journal of surgery case reports · 2022Article
- Comparison of LRINEC Scoring System with Finger Test and Histopathological Examination for Necrotizing Fasciitis.Surgery journal (New York, N.Y.) · 2022Article
- Necrotizing Soft Tissue Infections, the Challenge Remains.Frontiers in surgery · 2021Article
- Clostridial Gas Gangrene - A Rare but Deadly Infection: Case series and Comparison to Other Necrotizing Soft Tissue Infections.Orthopaedic surgery · 2020Article
- Complement Activation Is Associated With Mortality in Patients With Necrotizing Soft-Tissue Infections-A Prospective Observational Study.Frontiers in immunology · 2020Observational
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeSevere necrotizing soft-tissue infections (NSTIs) require immediate early surgical treatment to avoid adverse outcomes. This study aims to determine the impact of early surgery and comorbid conditions on the outcomes of NSTIs.
methodsA retrospective cohort study was performed on all subjects presenting with NSTI at an academic medical center between 2005 and 2016. Patients were identified based on ICD codes. Those under the age of 18 or with intraoperative findings not consistent with NSTI diagnosis were excluded.
resultsThere were 115 patients with a confirmed diagnosis of NSTI with a mean age of 55 ± 18 years; 41% were females and 55% were diabetics. Thirty percent of patients underwent early surgery (< 6 h). There were no significant differences between groups in baseline characteristics. The late group (≥ 6 h) had prolonged hospital stay (38 vs. 23 days, p < 0.008) in comparison to the early group (< 6 h). With every 1 h delay in time to surgery, there is a 0.268 day increase in length of stay, adjusted for these other variables: alcohol abuse, number of debridements, peripheral vascular disease, previous infection and clinical necrosis. Mortality was 16.5%. Multivariable analysis revealed that alcohol abuse, peripheral vascular disease, diabetes, obesity, hypothyroidism, and presence of COPD were associated with an increase in mortality.
conclusionsEarly surgical intervention in patients with severe necrotizing soft-tissue infections reduces length of hospital stay. Presence of comorbid conditions such as alcohol abuse, peripheral vascular disease, diabetes, obesity and hypothyroidism were associated with increased mortality.
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