Evidence map›Paper›PMID 29789657›Full record

ArticleScientific reports2018

The COOH-terminal domain of huntingtin interacts with RhoGEF kalirin and modulates cell survival.

Hollis McClory, Xiaolong Wang, Ellen Sapp, Leah W Gatune, Maria Iuliano, Chiu-Yi Wu, Gina Nathwani, Kimberly B Kegel-Gleason, Marian DiFiglia, Xueyi Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.5field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Are Methylation Patterns in theInternational journal of molecular sciences · 2024
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Hollis McCloryLaboratory of Cellular Neurobiology and Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, 02129, USA.
Xiaolong WangSchool of Pharmacy, Shanghai Jiao Tong University, Minhang District, Shanghai, China.
Ellen SappLaboratory of Cellular Neurobiology and Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, 02129, USA.
Leah W GatuneLaboratory of Cellular Neurobiology and Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, 02129, USA.
Maria IulianoLaboratory of Cellular Neurobiology and Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, 02129, USA.
Chiu-Yi WuLaboratory of Cellular Neurobiology and Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, 02129, USA.
Gina NathwaniLaboratory of Cellular Neurobiology and Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, 02129, USA.
Kimberly B Kegel-GleasonLaboratory of Cellular Neurobiology and Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, 02129, USA.
Marian DiFigliaLaboratory of Cellular Neurobiology and Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, 02129, USA.
Xueyi LiLaboratory of Cellular Neurobiology and Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, 02129, USA. Xueyi.Li@mgh.harvard.edu.
Harvard University · USMassachusetts General Hospital · USShanghai Jiao Tong University · CN

Funding

Role of Huntingtin in Vesicle TransportR01NS035711 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI DIFIGLIA, MARIAN · 1998 to 2005
$3.0M
Increase Rab11 Activity as HD TherapyR01NS074381 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI DIFIGLIA, MARIAN · 2011 to 2014
$1.4M
NINDS NIH HHS R01 NS035711NINDS NIH HHS R01 NS074381
6 · The paper itself

Abstract

Human huntingtin (Htt) contains 3144 amino acids and has an expanded polyglutamine region near the NH

Indexed as

Protein Interaction Domains and MotifsAnimalsCells, CulturedCell SurvivalGuanine Nucleotide Exchange FactorsHumansHuntingtin ProteinMCF-7 CellsMiceMice, TransgenicProtein BindingProtein Serine-Threonine KinasesRho Guanine Nucleotide Exchange FactorsGuanine Nucleotide Exchange FactorsHTT protein, humanHtt protein, mouseHuntingtin ProteinKALRN protein, humanKALRN protein, mouseProtein Serine-Threonine KinasesRho Guanine Nucleotide Exchange Factors

Identifiers

PMID29789657
PMCPMC5964228
OpenAlexW2803267366

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.