ArticleScientific reports2018
The Diversity of Chemoprotective Glucosinolates in Moringaceae (Moringa spp.).
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 85 citations in OpenAlex.
- Insights into glucomoringin biosynthesis in moringa sprouts through integrated transcriptomic and metabolomic analyses.Food chemistry. Molecular sciences · 2026Article
- Therapeutic Potential ofJournal of inflammation research · 2026Review
- A Comprehensive Review of Germination Impact on Moringa Seeds and Sprouts: Physiological and Biochemical Changes, Bioactive Compounds, Health Benefits, and Food Applications.Comprehensive reviews in food science and food safety · 2025Review
- Effect of MaternalCurrent developments in nutrition · 2025Article
- Bioavailability, Human Metabolism, and Dietary Interventions of Glucosinolates and Isothiocyanates: Critical Insights and Future Perspectives.Foods (Basel, Switzerland) · 2025Review
- Biological Activities of Glucosinolate and Its Enzymatic Product inInternational journal of molecular sciences · 2025Article
- Unveiling the Miracle Tree: Therapeutic Potential ofBiomedicines · 2025Review
- Antibacterial activity ofFrontiers in microbiology · 2025Article
- The Effect ofAntioxidants (Basel, Switzerland) · 2024Article
- Crop Improvement ofBiology · 2024Article
- Comparative Metabolomic Analysis ofInternational journal of molecular sciences · 2024Article
- Monitoring Indian "Superfood" Moringa oleifera Lam. - species-specific PCR-fingerprint-based authentication for more consumer safety.NPJ science of food · 2024Article
- Studying Salt-Induced Shifts in Gene Expression Patterns of Glucosinolate Transporters and Glucosinolate Accumulation in Two ContrastingMetabolites · 2024Article
- The role of isothiocyanate-rich plants and supplements in neuropsychiatric disorders: a review and update.Frontiers in nutrition · 2024Review
- Profiling of Nutritionally Vital Bioactive Compounds in Emerging Green Leafy Vegetables: A Comparative Study.Foods (Basel, Switzerland) · 2022Article
- Miracle TreePlants (Basel, Switzerland) · 2022Review
- Chromosome-scale assembly of the Moringa oleifera Lam. genome uncovers polyploid history and evolution of secondary metabolism pathways through tandem duplication.The plant genome · 2022Article
- Article
- Sulforaphane and Its Bifunctional Analogs: Synthesis and Biological Activity.Molecules (Basel, Switzerland) · 2022Review
- Evidence from a Systematic Review and Meta-Analysis Pointing to the Antidiabetic Effect of Polyphenol-Rich Plant Extracts fromCurrent issues in molecular biology · 2022Review
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glucosinolates (GS) are metabolized to isothiocyanates that may enhance human healthspan by protecting against a variety of chronic diseases. Moringa oleifera, the drumstick tree, produces unique GS but little is known about GS variation within M. oleifera, and even less in the 12 other Moringa species, some of which are very rare. We assess leaf, seed, stem, and leaf gland exudate GS content of 12 of the 13 known Moringa species. We describe 2 previously unidentified GS as major components of 6 species, reporting on the presence of simple alkyl GS in 4 species, which are dominant in M. longituba. We document potent chemoprotective potential in 11 of 12 species, and measure the cytoprotective activity of 6 purified GS in several cell lines. Some of the unique GS rank with the most powerful known inducers of the phase 2 cytoprotective response. Although extracts of most species induced a robust phase 2 cytoprotective response in cultured cells, one was very low (M. longituba), and by far the highest was M. arborea, a very rare and poorly known species. Our results underscore the importance of Moringa as a chemoprotective resource and the need to survey and conserve its interspecific diversity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.