ArticleScientific reports2018
Neuromodulation of sensory networks in monkey brain by focused ultrasound with MRI guidance and detection.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 1 synthesis or guideline pooled it, 102 citations in OpenAlex.
- Brain Modulatory Effects by Low-Intensity Transcranial Ultrasound Stimulation (TUS): A Systematic Review on Both Animal and Human Studies.Frontiers in neuroscience · 2019Pooled it
- Transcranial focused ultrasound modulates spiking, LFP, and BOLD activity in the primate thalamus.Nature communications · 2026Article
- Ultrasound Modulation of Visual Circuits in Mice Independent of Auditory Confound.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Magnetic Resonance Imaging Monitoring of the Safety of Repeated Low-Intensity Focused Ultrasound Exposure at Three Brain Locations.Neuromodulation : journal of the International Neuromodulation Society · 2026Article
- A human-compatible gradient coil for visualizing ultrasound propagation.Magnetic resonance imaging · 2025Article
- Modulating nociception networks: the impact of low-intensity focused ultrasound on thalamocortical connectivity.Brain communications · 2025Article
- Focal Volume, Acoustic Radiation Force, and Strain in Two-Transducer Regimes.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2024Article
- Brain activity changes after high/low frequency stimulation in a nonhuman primate model of central post-stroke pain.Scientific reports · 2024Article
- Clinical Potential of Transcranial Focused Ultrasound for Neurorehabilitation in Pediatric Cancer Survivors.Brain sciences · 2024Review
- Intravital photoacoustic brain stimulation with high-precision.Journal of biomedical optics · 2024Review
- Non-invasive neuromodulation of sub-regions of the human insula differentially affect pain processing and heart-rate variability.bioRxiv : the preprint server for biology · 2023Article
- Pulsed Focused Ultrasound Reduces Hippocampal Volume Loss and Improves Behavioral Performance in the Kainic Acid Rat Model of Epilepsy.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023Article
- Safety of Clinical Ultrasound Neuromodulation.Brain sciences · 2022Review
- Low Intensity Focused Ultrasound for Epilepsy- A New Approach to Neuromodulation.Epilepsy currents · 2022Article
- Acoustic Holograms for Bilateral Blood-Brain Barrier Opening in a Mouse Model.IEEE transactions on bio-medical engineering · 2022Article
- Potential Goals, Challenges, and Safety of Focused Ultrasound Application for Central Nervous System Disorders.Current neuropharmacology · 2022Article
- A review of the bioeffects of low-intensity focused ultrasound and the benefits of a cellular approach.Frontiers in physiology · 2022Review
- Current State of Potential Mechanisms Supporting Low Intensity Focused Ultrasound for Neuromodulation.Frontiers in human neuroscience · 2022Review
- Ultrasound modulation of macaque prefrontal cortex selectively alters credit assignment-related activity and behavior.Science advances · 2021Article
- Design and construction of an interchangeable RF coil system for rodent spinal cord MR imaging at 9.4 T.Magnetic resonance imaging · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Focused ultrasound (FUS) has gained recognition as a technique for non-invasive neuromodulation with high spatial precision and the ability to both excite and inhibit neural activity. Here we demonstrate that MRI-guided FUS is capable of exciting precise targets within areas 3a/3b in the monkey brain, causing downstream activations in off-target somatosensory and associated brain regions which are simultaneously detected by functional MRI. The similarity between natural tactile stimulation-and FUS- evoked fMRI activation patterns suggests that FUS likely can excite populations of neurons and produce associated spiking activities that may be subsequently transmitted to other functionally related touch regions. The across-region differences in fMRI signal changes relative to area 3a/3b between tactile and FUS conditions also indicate that FUS modulated the tactile network differently. The significantly faster rising (>1 sec) fMRI signals elicited by direct FUS stimulation at the targeted cortical region suggest that a different neural hemodynamic coupling mechanism may be involved in generating fMRI signals. This is the first demonstration of imaging neural excitation effects of FUS with BOLD fMRI on a specific functional circuit in non-human primates.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.