Evidence map›Paper›PMID 29789580›Full record

ArticleScientific reports2018

The Effects of Anti-LAP Monoclonal Antibody Down-regulation of CD4+LAP+ T Cells on Allogeneic Corneal Transplantation in Mice.

Shang Li, Hongshuang Lu, Ruti Sella, Wei Zhang, Hongwei Dong, Chungang Guo, Natalie A Afshari, Zhiqiang Pan, Ying Jie

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Observational
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Shang LiBeijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmic and Visual Science Key Lab, Beijing, China.ORCID 0000-0002-1697-6708
Hongshuang LuBeijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmic and Visual Science Key Lab, Beijing, China.
Ruti SellaShiley Eye Institute, Department of Ophthalmology, University of California San Diego, La Jolla, CA, USA.
Wei ZhangDepartment of Ophthalmology, Beijing YouAn Hospital, Capital Medical University, Beijing, China.
Hongwei DongDepartment of Ophthalmology, Beijing YouAn Hospital, Capital Medical University, Beijing, China.
Chungang GuoDepartment of Ophthalmology, Beijing YouAn Hospital, Capital Medical University, Beijing, China.
Natalie A AfshariShiley Eye Institute, Department of Ophthalmology, University of California San Diego, La Jolla, CA, USA.
Zhiqiang PanBeijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmic and Visual Science Key Lab, Beijing, China. panyj0526@sina.com.
Ying JieBeijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmic and Visual Science Key Lab, Beijing, China. jie_yingcn@aliyun.com.ORCID 0000-0003-2649-8241
Beijing Tongren Hospital · CNCapital Medical University · CNUniversity of California San Diego · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CD4+latency-associated peptide (LAP)+ T cells are a newly discovered T cell subset with suppressive function on immune responses. In this study, we investigate the role of CD4+LAP+ T cells on mice corneal allograft survival by down-regulating their expression using anti-LAP mAb. We show that a blockage of LAP leads to a decrease in the percentage of T cells expressing CD4+Foxp3+, CD4+GARP+, CD4+LAP+ and CD4+IL-10+ in the lymph nodes and spleens of mice undergoing orthotopic penetrating transplantation of corneal allograft, without affecting corneal graft survival. In addition, higher percentages of CD4+IFN-γ+ and CD4+IL-17A+ T cells in the lymph nodes and spleens, as well as TNF, IFN-γ, IL-17A and IL-6 levels in the aqueous humor, significantly increase in mice with rejected corneal grafts. The expression of TGF-β1 decreases in corneal grafts during corneal rejection period. It is therefore possible that anti-LAP mAb can down-regulate the regulatory T cell subsets with its immunosuppressive effects. The rejection of corneal grafts seems to mainly be associated with the up-regulation of Th1 and Th17 cell subsets in peripheral lymph nodes.

Indexed as

Antibody-Dependent Cell CytotoxicityAnimalsAntibodies, MonoclonalCD4-Positive T-LymphocytesCorneaCorneal TransplantationDown-RegulationGraft RejectionGraft SurvivalImmune ToleranceMaleMiceMice, Inbred BALB CMice, Inbred C57BLPeptidesProtein PrecursorsAntibodies, Monoclonallatency-associated propeptide, TGF-betaPeptidesProtein PrecursorsTransforming Growth Factor beta

Identifiers

PMID29789580
PMCPMC5964070
OpenAlexW2805563522

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.