ReviewExperimental & molecular medicine2018
The wide utility of rabbits as models of human diseases.
Erratum issuedOpen access · goldAbstract readReview
In one paragraph
Review in Experimental & molecular medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 103 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
103citing papers in PubMed, 2 pooled it
10.8field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
103 citing papers in PubMed, 2 syntheses or guidelines pooled it, 208 citations in OpenAlex.
- A systematic review and meta-analyses on animal models used in bone adhesive research.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022Pooled it
- Mitochondrial transplantation therapy for ischemia reperfusion injury: a systematic review of animal and human studies.Journal of translational medicine · 2021Pooled it
- Rapid Generation of High-Affinity Rabbit Anti-Mouse IgG Monoclonal Antibodies by High-Throughput Single-B-Cell Sorting and Recombinant Expression.Current issues in molecular biology · 2026Article
- Towards clinical translation of nanomedicines: Formulation scale-up and model systems.Advanced drug delivery reviews · 2026Review
- Functional Immunonutraceutical Supplementation Enhances Humoral and Innate Immune Dynamics in a Controlled Immune-Challenge Rabbit Model.Nutrients · 2026Article
- Understanding the impact of Klebsiella pneumoniae K-Antigen based MAPS vaccine design on the immune response in animal models.PLoS pathogens · 2026Article
- Rabbit Immune Cell Function: In Vitro Assays for Immunological Assessment Studies Using Flow Cytometry.Biotech (Basel (Switzerland)) · 2026Article
- Degradation behavior and biological properties of a novel biodegradable zinc alloy biliary stent.Bioactive materials · 2026Article
- UNICOR-v, a Pan-Coronavirus Subunit Vaccine, Demonstrates Immunogenicity and Efficacy Against MERS-CoV Infection.Vaccines · 2026Article
- Genome-wide transcriptional landscape ofFrontiers in immunology · 2026Article
- A rabbit model of acute bacteremia and sepsis caused by vancomycin-resistantFrontiers in cellular and infection microbiology · 2026Article
- Phosphosulindac (OXT-328) restores the suppressed corneal sensitivity in rabbits with dry eye disease: therapeutic implications.Frontiers in drug delivery · 2026Article
- Widespread presence of novel gammaherpesviruses in lagomorph species (Oryctolagus cuniculus, Lepus spp. and Ochotona alpina).Virology journal · 2025Article
- Liver-Microbiome Crosstalk Mediates the Protective Effects of Artemisinin in Clostridium perfringens Models.Microbial biotechnology · 2025Article
- Development and characterization of antibodies againstOpen veterinary journal · 2025Article
- Contributions of large and agricultural animal models to immunology.Journal of immunology (Baltimore, Md. : 1950) · 2025Review
- Comparative Analysis of Intestinal TLR4 Gene Expression and Functional Verification in Lepus yarkandensis and Oryctolagus cuniculus.Biochemical genetics · 2025Article
- Demand analysis of rabbits for meat, fur and companionship in India.Tropical animal health and production · 2025Article
- The Path Towards Effective Long-Lasting Tissue-Targeted Prime/Pull/Keep Herpes Simplex Therapeutic Vaccines.Vaccines · 2025Review
- The Role of Myxoma Virus Immune Modulators and Host Range Factors in Pathogenesis and Species Leaping.Viruses · 2025Review
43 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
37 authors at 18 institutions in 6 countries.
Pedro J EstevesCIBIO, InBIO, Research Network in Biodiversity and Evolutionary Biology, Universidade do Porto, Campus de Vairão, Rua Padre Armando Quintas, 4485-661, Vairão, Portugal. pjesteves@cibio.up.pt.
Joana AbrantesCIBIO, InBIO, Research Network in Biodiversity and Evolutionary Biology, Universidade do Porto, Campus de Vairão, Rua Padre Armando Quintas, 4485-661, Vairão, Portugal.
Hanna-Mari BaldaufMax von Pettenkofer Institute and Gene Center, Virology, National Reference Center for Retroviruses, Faculty of Medicine, LMU München, 81377, Munich, Germany.
Lbachir BenMohamedLaboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, University of California, Irvine, School of Medicine, Irvine, CA, 92697, USA.
Yuxing ChenDepartment of Medicine, University of Massachusetts Medical School, Worcester, MA, 01605, USA.
Neil ChristensenDepartments of Pathology, Microbiology and Immunology, and Comparative Medicine, Penn State University, Hershey, PA, USA.
Javier González-GallegoInstitute of Biomedicine (IBIOMED) and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), University of León, 24071, León, Spain.
Lorenzo GiacaniDepartments of Medicine and Global Health, University of Washington, Seattle, USA.
Jiafen HuDepartments of Pathology, Microbiology and Immunology, and Comparative Medicine, Penn State University, Hershey, PA, USA.
Gilla KaplanBill and Melinda Gates Foundation, Seattle, WA, USA.
Oliver T KepplerMax von Pettenkofer Institute and Gene Center, Virology, National Reference Center for Retroviruses, Faculty of Medicine, LMU München, 81377, Munich, Germany.
Katherine L KnightDepartment of Microbiology and Immunology, Loyola University Chicago, Maywood, IL, 60153, USA.
Xiang-Peng KongDepartment of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY10016, USA.
Dennis K LanningDepartment of Microbiology and Immunology, Loyola University Chicago, Maywood, IL, 60153, USA.
Jacques Le PenduCRCINA, Inserm, Université d'Angers, Université de Nantes, Nantes, France.
Ana Lemos de MatosThe Biodesign Institute, Center for Immunotherapy, Vaccines, and Virotherapy, Arizona State University, Tempe, AZ, 85287-5401, USA.
Jia LiuDepartment of Microbiology and Immunology, University of Arkansas for Medical Sciences (UAMS), Little Rock, AR, 72205, USA.
Shuying LiuDepartment of Medicine, University of Massachusetts Medical School, Worcester, MA, 01605, USA.
Ana M LopesCIBIO, InBIO, Research Network in Biodiversity and Evolutionary Biology, Universidade do Porto, Campus de Vairão, Rua Padre Armando Quintas, 4485-661, Vairão, Portugal.
Shan LuDepartment of Medicine, University of Massachusetts Medical School, Worcester, MA, 01605, USA.
Sheila LukehartDepartments of Medicine and Global Health, University of Washington, Seattle, USA.
Yukari C ManabeDivision of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Fabiana NevesCIBIO, InBIO, Research Network in Biodiversity and Evolutionary Biology, Universidade do Porto, Campus de Vairão, Rua Padre Armando Quintas, 4485-661, Vairão, Portugal.
Grant McFaddenThe Biodesign Institute, Center for Immunotherapy, Vaccines, and Virotherapy, Arizona State University, Tempe, AZ, 85287-5401, USA.
Ruimin PanDepartment of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY10016, USA.
Xuwen PengDepartments of Pathology, Microbiology and Immunology, and Comparative Medicine, Penn State University, Hershey, PA, USA.
Patricia de Sousa-PereiraCIBIO, InBIO, Research Network in Biodiversity and Evolutionary Biology, Universidade do Porto, Campus de Vairão, Rua Padre Armando Quintas, 4485-661, Vairão, Portugal.
Ana PinheiroCIBIO, InBIO, Research Network in Biodiversity and Evolutionary Biology, Universidade do Porto, Campus de Vairão, Rua Padre Armando Quintas, 4485-661, Vairão, Portugal.
Masmudur RahmanThe Biodesign Institute, Center for Immunotherapy, Vaccines, and Virotherapy, Arizona State University, Tempe, AZ, 85287-5401, USA.
Natalie Ruvoën-ClouetCRCINA, Inserm, Université d'Angers, Université de Nantes, Nantes, France.
Selvakumar SubbianThe Public Health Research Institute (PHRI) at New Jersey Medical School, Rutgers Biomedical and Health Sciences (RBHS), Rutgers University, Newark, NJ, USA.
Maria Jesús TuñónInstitute of Biomedicine (IBIOMED) and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), University of León, 24071, León, Spain.
Wessel van der LooCIBIO, InBIO, Research Network in Biodiversity and Evolutionary Biology, Universidade do Porto, Campus de Vairão, Rua Padre Armando Quintas, 4485-661, Vairão, Portugal.
Michael VaineDepartment of Medicine, University of Massachusetts Medical School, Worcester, MA, 01605, USA.
Laura E ViaTubercolosis Research Section, Laboratory of Clinical Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Shixia WangDepartment of Medicine, University of Massachusetts Medical School, Worcester, MA, 01605, USA.
Rose MageLaboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. rmage@niaid.nih.gov.
University of Massachusetts Chan Medical School · USUniversidade do Porto · PTArizona State University · USLoyola University Chicago · USLudwig-Maximilians-Universität München · DEPennsylvania State University · USNational Institutes of Health · USNew York University · USSeattle University · USUniversidad de León · ESBill & Melinda Gates Foundation · USCooperativa de Ensino Superior Politécnico e Universitário · PTIrvine University · USJohns Hopkins Medicine · USNantes Université · FRRutgers, The State University of New Jersey · USUniversité d'Angers · FRUniversity of Arkansas for Medical Sciences · US
Funding
University of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1MStudy of the Cell-specific Inflammasome Responses During Defense Against Gram-negative BacteriaP20GM103625 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI SMELTZER, MARK S · 2012 to 2021
$21.5MExperimental Animal Models of TB: Chemotherapeutics and ImagingZIAAI000734 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI BARRY, CLIFTON · 2009 to 2025
$19.6MVaccines to Induce Functional Antibodies Targeting the V2 Loop P01AI100151 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI GORNY, MIROSLAW K · 2012 to 2017
$15.4MVariation in HIV-1 R5 Envs: Consequences for tropism, neutralization & vaccinesP01AI082274 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI LU, SHAN · 2009 to 2013
$9.7MTherapeutic Ocular HSV Vaccine in HLA Transgenic RabbitsR01EY019896 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI BENMOHAMED, LBACHIR · 2010 to 2025
$5.1MSomatic Diversification of Immunoglobulin Genes in GALTR01AI050260 · NIAID · LOYOLA UNIVERSITY CHICAGO · PI KNIGHT, KATHERINE L. · 2001 to 2015
$5.1MPapillomavirus Host InterationR01CA047622 · NCI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI CHRISTENSEN, NEIL D · 1988 to 2015
$3.8MMaintaining B cell immunity with aged B lymphocytesR01AI068390 · NIAID · LOYOLA UNIVERSITY CHICAGO · PI KNIGHT, KATHERINE L. · 2007 to 2015
$3.4MMechanisms of CD8+ T Cell Dynamics in Recurrent Ocular Herpetic DiseaseR01EY026103 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI BENMOHAMED, LBACHIR · 2016 to 2019
$1.5MBlockade of T-cell Co-Inhibitory Pathways & Immunotherapy to Prevent Ocular HerpeR01EY024618 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI BENMOHAMED, LBACHIR · 2014 to 2016
$1.2MInteraction of HSV-1 LAT Gene &Dendritic Cells FunctionR03EY014017 · NEI · UNIVERSITY OF CALIFORNIA IRVINE · PI BENMOHAMED, LBACHIR · 2002 to 2004
$456kNCATS NIH HHS UL1 TR001414NCI NIH HHS R01 CA047622NEI NIH HHS R01 EY019896NEI NIH HHS R01 EY024618NEI NIH HHS R01 EY026103NEI NIH HHS R03 EY014017NIAID NIH HHS P01 AI082274NIAID NIH HHS P01 AI100151NIAID NIH HHS R01 AI050260NIAID NIH HHS R01 AI068390NIAID NIH HHS R03 AI119619NIAID NIH HHS R21 AI110902NIGMS NIH HHS P20 GM103625
Abstract
Studies using the European rabbit Oryctolagus cuniculus contributed to elucidating numerous fundamental aspects of antibody structure and diversification mechanisms and continue to be valuable for the development and testing of therapeutic humanized polyclonal and monoclonal antibodies. Additionally, during the last two decades, the use of the European rabbit as an animal model has been increasingly extended to many human diseases. This review documents the continuing wide utility of the rabbit as a reliable disease model for development of therapeutics and vaccines and studies of the cellular and molecular mechanisms underlying many human diseases. Examples include syphilis, tuberculosis, HIV-AIDS, acute hepatic failure and diseases caused by noroviruses, ocular herpes, and papillomaviruses. The use of rabbits for vaccine development studies, which began with Louis Pasteur's rabies vaccine in 1881, continues today with targets that include the potentially blinding HSV-1 virus infection and HIV-AIDS. Additionally, two highly fatal viral diseases, rabbit hemorrhagic disease and myxomatosis, affect the European rabbit and provide unique models to understand co-evolution between a vertebrate host and viral pathogens.
Indexed as
Disease Models, AnimalAnimalsBiological EvolutionHumansImmune SystemImmunityRabbits
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.