ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018
Subthalamic Nucleus Neurons Differentially Encode Early and Late Aspects of Speech Production.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05493670 (Role of Subthalamic Nucleus in Speech and Movement Among People With Parkinson's Disease as Revealed by Intraoperative Recordings and Deep Brain Stimulation), which is not on this map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Role of Subthalamic Nucleus in Speech and Movement Among People With Parkinson's Disease as Revealed by Intraoperative Recordings and Deep Brain Stimulation
Who cites it
26 citing papers in PubMed, 50 citations in OpenAlex.
- Differential Cognitive Effects of Unilateral Subthalamic Nucleus Deep Brain Stimulation for Parkinson's Disease.Annals of neurology · 2024Trial
- Neurons of the human subthalamic nucleus engage with local delta frequency processes during action cancellation.Nature communications · 2026Article
- Distinct Temporal Patterns of Human Neural Firing in the Subthalamic Nucleus During Speech and Orofacial Movement.bioRxiv : the preprint server for biology · 2025Article
- Spike-phase coupling of subthalamic neurons to posterior perisylvian cortex predicts speech sound accuracy.Nature communications · 2025Article
- Subthalamic nucleus neurons encode syllable sequence and phonetic characteristics during speech.Journal of neurophysiology · 2024Article
- Acoustic assessment in mandarin-speaking Parkinson's disease patients and disease progression monitoring and brain impairment within the speech subsystem.NPJ Parkinson's disease · 2024Review
- Subthalamic nucleus-language network connectivity predicts dopaminergic modulation of speech function in Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- A neurocomputational view of the effects of Parkinson's disease on speech production.Frontiers in human neuroscience · 2024Article
- A supervised data-driven spatial filter denoising method for speech artifacts in intracranial electrophysiological recordings.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- A 3D atlas of functional human brain energetic connectome based on neuropil distribution.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Differential cognitive effects of unilateral left and right subthalamic nucleus deep brain stimulation for Parkinson disease.medRxiv : the preprint server for health sciences · 2023Article
- Lexicality-Modulated Influence of Auditory Cortex on Subthalamic Nucleus During Motor Planning for Speech.Neurobiology of language (Cambridge, Mass.) · 2023Article
- Human subthalamic nucleus neurons differentially encode speech and limb movement.Frontiers in human neuroscience · 2023Article
- Speech artifact is also present in spike data.NeuroImage · 2022Article
- Review
- Differentiation of speech-induced artifacts from physiological high gamma activity in intracranial recordings.NeuroImage · 2022Article
- Articulatory Gain Predicts Motor Cortex and Subthalamic Nucleus Activity During Speech.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Proceedings of the 10th annual deep brain stimulation think tank: Advances in cutting edge technologies, artificial intelligence, neuromodulation, neuroethics, interventional psychiatry, and women in neuromodulation.Frontiers in human neuroscience · 2022Article
- Simultaneously recorded subthalamic and cortical LFPs reveal different lexicality effects during reading aloud.Journal of neurolinguistics · 2021Article
- Stimulation of the Subthalamic Nucleus Changes Cortical-Subcortical Blood Flow Patterns During Speech: A Positron Emission Tomography Study.Frontiers in neurology · 2021Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 3 countries.
Funding
Abstract
Basal ganglia-thalamocortical loops mediate all motor behavior, yet little detail is known about the role of basal ganglia nuclei in speech production. Using intracranial recording during deep brain stimulation surgery in humans with Parkinson's disease, we tested the hypothesis that the firing rate of subthalamic nucleus neurons is modulated in sync with motor execution aspects of speech. Nearly half of 79 unit recordings exhibited firing-rate modulation during a syllable reading task across 12 subjects (male and female). Trial-to-trial timing of changes in subthalamic neuronal activity, relative to cue onset versus production onset, revealed that locking to cue presentation was associated more with units that decreased firing rate, whereas locking to speech onset was associated more with units that increased firing rate. These unique data indicate that subthalamic activity is dynamic during the production of speech, reflecting temporally-dependent inhibition and excitation of separate populations of subthalamic neurons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.