Evidence map›Paper›PMID 29789310›Full record

ArticleDevelopment (Cambridge, England)2018

CLERK is a novel receptor kinase required for sensing of root-active CLE peptides in

Pauline Anne, Amelia Amiguet-Vercher, Benjamin Brandt, Lothar Kalmbach, Niko Geldner, Michael Hothorn, Christian S Hardtke

Open access · hybridAbstract read
In one paragraph

Article in Development (Cambridge, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
15.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 78 citations in OpenAlex.

  1. Review
  2. Review
  3. Receptor kinase pathway signal tuning through a nontranscriptional incoherent feedforward loop.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Peptide hormones in plants.Molecular horticulture · 2025
    Review
  5. Small Peptides: Orchestrators of Plant Growth and Developmental Processes.International journal of molecular sciences · 2024
    Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. WOX going on: CLE peptides in plant development.Current opinion in plant biology · 2021
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Pauline AnneDepartment of Plant Molecular Biology, University of Lausanne, Biophore Building, CH-1015 Lausanne, Switzerland.
Amelia Amiguet-VercherDepartment of Plant Molecular Biology, University of Lausanne, Biophore Building, CH-1015 Lausanne, Switzerland.
Benjamin BrandtStructural Plant Biology Laboratory, Department of Botany and Plant Biology, University of Geneva, CH-1211 Geneva, Switzerland.
Lothar KalmbachDepartment of Plant Molecular Biology, University of Lausanne, Biophore Building, CH-1015 Lausanne, Switzerland.
Niko GeldnerDepartment of Plant Molecular Biology, University of Lausanne, Biophore Building, CH-1015 Lausanne, Switzerland.
Michael HothornStructural Plant Biology Laboratory, Department of Botany and Plant Biology, University of Geneva, CH-1211 Geneva, Switzerland.
Christian S HardtkeDepartment of Plant Molecular Biology, University of Lausanne, Biophore Building, CH-1015 Lausanne, Switzerland christian.hardtke@unil.ch.ORCID 0000-0003-3203-1058
University of Lausanne · CHUniversity of Geneva · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CLAVATA3/EMBRYO SURROUNDING REGION (CLE) peptides are secreted endogenous plant ligands that are sensed by receptor kinases (RKs) to convey environmental and developmental inputs. Typically, this involves an RK with narrow ligand specificity that signals together with a more promiscuous co-receptor. For most CLEs, biologically relevant (co-)receptors are unknown. The dimer of the receptor-like protein CLAVATA 2 (CLV2) and the pseudokinase CORYNE (CRN) conditions perception of so-called root-active CLE peptides, the exogenous application of which suppresses root growth by preventing protophloem formation in the meristem.

Indexed as

ArabidopsisArabidopsis ProteinsGenome, PlantMembrane ProteinsPlant RootsPlants, Genetically ModifiedProtein Serine-Threonine KinasesArabidopsis ProteinsAt2g23950 protein, ArabidopsisAT2G27250 protein, ArabidopsisCLE26 protein, ArabidopsisCLE45 protein, ArabidopsisCLV2 protein, ArabidopsisMembrane ProteinsNIK1 protein, ArabidopsisProtein Serine-Threonine KinasesSARK protein, ArabidopsisArabidopsisBAM3CLE peptideProtophloemReceptor kinaseRoot

Identifiers

PMID29789310
PMCPMC6001375
OpenAlexW2803205867

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.