Evidence map›Paper›PMID 29789205›Full record

ArticleParkinsonism & related disorders2018

Genetic variants related to urate and risk of Parkinson's disease.

Katherine C Hughes, Xiang Gao, Eilis J O'Reilly, Iris Y Kim, Molin Wang, Marc G Weisskopf, Michael A Schwarzschild, Alberto Ascherio

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Parkinsonism & related disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Plasma urate concentrations and possible REM sleep behavior disorder.Annals of clinical and translational neurology · 2019
    Trial
  2. Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Katherine C HughesDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA. Electronic address: kch460@mail.harvard.edu.
Xiang GaoDepartment of Nutritional Health, The Pennsylvania State University, University Park, PA, USA.
Eilis J O'ReillyDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA; School of Public Health, College of Medicine, University College Cork, Ireland.
Iris Y KimDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Molin WangDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Marc G WeisskopfDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Michael A SchwarzschildMassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Boston, MA, USA.
Alberto AscherioDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Harvard University · USBrigham and Women's Hospital · USMassachusetts General Hospital · USPennsylvania State University · US

Funding

Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3M
Phase 3 trial of inosine for Parkinson's disease CCCU01NS090259 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI SCHWARZSCHILD, MICHAEL A · 2015 to 2019
$16.9M
Cancer Epidemiology Cohort in Male Health ProfessionalsUM1CA167552 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI WILLETT, WALTER C. · 2012 to 2016
$11.5M
Urate as a Predictor of Parkinson's Disease Risk and ProgressionR01NS061858 · NINDS · HARVARD SCHOOL OF PUBLIC HEALTH · PI ASCHERIO, ALBERTO · 2009 to 2013
$3.4M
2017 Parkinson Study Group Symposium and TrainingU13NS103523 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI SCHWARZSCHILD, MICHAEL A · 2017 to 2017
$25k
2016 Parkinson Study Group Symposium and TrainingR13NS098746 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI SCHWARZSCHILD, MICHAEL A · 2016 to 2016
$20k
NCI NIH HHS UM1 CA167552NCI NIH HHS UM1 CA186107NINDS NIH HHS R01 NS061858NINDS NIH HHS R13 NS098746NINDS NIH HHS U01 NS090259NINDS NIH HHS U13 NS103523
6 · The paper itself

Abstract

introductionHigher urate concentrations have been associated with a lower risk of developing Parkinson's disease (PD) and with slower rates of clinical decline in PD patients. Whether these associations reflect a neuroprotective effect of urate is unclear. Our objective was to assess whether genetic variants that modify circulating urate levels are also associated with altered PD risk.

methodsParticipants were from three large ongoing cohort studies: the Nurses' Health Study (NHS), the Health Professionals Follow-up Study (HPFS), and the Cancer Prevention Study II Nutrition Cohort (CPS-IIN). We examined associations between single nucleotide polymorphisms (SNPs) in SLC2A9 and other genes involved in urate transport and PD risk using conditional logistic regression among 1451 cases and 3135 matched controls. We assessed associations between SNPs and plasma urate levels in a subset of 1174 control participants with linear regression models.

resultsWe found the expected associations between SNPs in SLC2A9 and plasma urate levels among men and women; however, SNPs in other genes tended not to be associated with urate. Each SNP in SLC2A9 explained less than 7% of the variance in plasma urate. We did not find significant associations between the SNPs in SLC2A9 and PD risk among men or women.

conclusionOur results do not support an association between genetic variants associated with circulating urate levels and risk of PD, but larger investigations are needed to determine whether the modest genetic effects on blood urate contribute to predict PD risk.

Indexed as

AgedCase-Control StudiesCohort StudiesFemaleGlucose Transport Proteins, FacilitativeHealth SurveysHumansMaleMiddle AgedParkinson DiseasePolymorphism, Single NucleotideRisk FactorsUric AcidGlucose Transport Proteins, FacilitativeSLC2A9 protein, humanUric AcidParkinson's diseaseUrate

Identifiers

PMID29789205
PMCPMC6120767
OpenAlexW2800226832

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.