Evidence map›Paper›PMID 29789006›Full record

ArticleBMC pulmonary medicine2018

Outcomes of lung transplantation in adults with bronchiectasis.

Jodie Birch, Syba S Sunny, Katy L M Hester, Gareth Parry, F Kate Gould, John H Dark, Stephen C Clark, Gerard Meachery, James Lordan, Andrew J Fisher and 2 more

Open access · goldAbstract read
In one paragraph

Article in BMC pulmonary medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Guideline
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Brazilian consensus on non-cystic fibrosis bronchiectasis.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2019
    Article
  9. Bronchiectasis: an emerging global epidemic.BMC pulmonary medicine · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Jodie BirchInstitute of Cellular Medicine, Newcastle University, M2060 Leech Building, The Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK.
Syba S SunnySir William Leech Centre for lung research, The Freeman Hospital, High Heaton, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, NE7 7DN, UK.
Katy L M HesterInstitute of Cellular Medicine, Newcastle University, M2060 Leech Building, The Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK.
Gareth ParryInstitute of Transplantation, The Freeman Hospital, High Heaton, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, NE7 7DN, UK.
F Kate GouldDepartment of Medical Microbiology, The Freeman Hospital, High Heaton, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, NE7 7DN, UK.
John H DarkInstitute of Transplantation, The Freeman Hospital, High Heaton, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, NE7 7DN, UK.
Stephen C ClarkInstitute of Transplantation, The Freeman Hospital, High Heaton, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, NE7 7DN, UK.
Gerard MeacheryInstitute of Transplantation, The Freeman Hospital, High Heaton, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, NE7 7DN, UK.
James LordanInstitute of Transplantation, The Freeman Hospital, High Heaton, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, NE7 7DN, UK.
Andrew J FisherInstitute of Cellular Medicine, Newcastle University, M2060 Leech Building, The Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK.
Paul A CorrisInstitute of Cellular Medicine, Newcastle University, M2060 Leech Building, The Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK.
Anthony De SoyzaInstitute of Cellular Medicine, Newcastle University, M2060 Leech Building, The Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK. Anthony.de-soyza@newcastle.ac.uk.ORCID http://orcid.org/0000-0002-8566-0344
Newcastle upon Tyne Hospitals NHS Foundation Trust · GBNewcastle University · GB

Funding

Medical Research Council MRC Partnership Grant (MR/L0011263/1)
6 · The paper itself

Abstract

backgroundLung transplantation is a well-established treatment for end-stage non-cystic fibrosis bronchiectasis (BR), though information regarding outcomes of transplantation remains limited. Our results of lung transplantation for Br are reported here.

methodsA retrospective review of case notes and transplantation databases was conducted for patients that had underwent lung transplantation for bronchiectasis at the Freeman Hospital between 1990 and 2013.

resultsFourty two BR patients underwent lung transplantation, the majority (39) having bilateral sequential lung transplantation. Mean age at transplantation was 47.1 years. Pre-transplantation osteoporosis was a significant non-pulmonary morbidity (48%). Polymicrobial infection was common, with Pseudomonas aeruginosa infection frequently but not universally observed (67%). Forced expiratory volume in 1 second (% predicted) improved from a pre-transplantation mean of 0.71 L (22% predicted) to 2.56 L (79 % predicted) at 1-year post-transplantation. Our survival results were 74% at 1 year, 64% at 3 years, 61% at 5 years and 48% at 10 years. Sepsis was a common cause of early post-transplantation deaths.

conclusionsLung transplantation for end-stage BR is a useful therapeutic option, with good survival and lung function outcomes. Survival values were similar to other bilateral lung transplants at our centre. Pre-transplantation Pseudomonas infection is common.

Indexed as

Lung TransplantationAdultBronchiectasisDatabases, FactualFemaleForced Expiratory VolumeHumansLungMaleMiddle AgedPostoperative ComplicationsPseudomonas InfectionsRetrospective StudiesSurvival AnalysisTime FactorsYoung AdultBronchiectasisPseudomonasTransplantation

Identifiers

PMID29789006
PMCPMC5964693
OpenAlexW2805917897

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.