Evidence map›Paper›PMID 29788993›Full record

ArticleCritical care (London, England)2018

Acetylcholine receptor antagonists in acute respiratory distress syndrome: much more than muscle relaxants.

Diana Jansen, Heder de Vries, Leo M A Heunks

Abstract readEditorial
In one paragraph

Article in Critical care (London, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Diana JansenDepartment of Anesthesiology, Radboud University Medical Center, Nijmegen, The Netherlands.
Heder de VriesDepartment of Intensive Care Medicine, VU University Medical Center Amsterdam, Amsterdam, The Netherlands.
Leo M A HeunksDepartment of Intensive Care Medicine, VU University Medical Center Amsterdam, Amsterdam, The Netherlands. L.Heunks@vumc.nl.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acetylcholine receptor antagonists have been shown to improve outcome in patients with severe acute respiratory distress syndrome. However, it is incompletely understood how these agents improve outcome. In the current editorial, we discuss the mechanisms of action of acetylcholine receptor antagonists beyond neuromuscular blockade.

Indexed as

Cholinergic AntagonistsHumansNeuromuscular Nondepolarizing AgentsRespiratory Distress SyndromeTreatment OutcomeCholinergic AntagonistsNeuromuscular Nondepolarizing AgentsAcetylcholineAcetylcholine receptorsAcute respiratory distress syndromeDirect anti-inflammatory effectLow tidal volume ventilationLung injury markersNeuromuscular blockersPartial neuromuscular blockadeRespiratory muscles

Identifiers

PMID29788993
PMCPMC5964732

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.