Evidence map›Paper›PMID 29788942›Full record

ArticleBMC musculoskeletal disorders2018

Use of autologous bone marrow stem cell implantation for osteonecrosis of the knee in sickle cell disease: a preliminary report.

Gildasio Daltro, Bruno Adelmo Franco, Thiago Batista Faleiro, Davi Araujo Veiga Rosário, Paula Braga Daltro, Roberto Meyer, Vitor Fortuna

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC musculoskeletal disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02448121 (Treatment for Hip, Knee, Ankle and Shoulder Osteonecrosis With Autologous Mononuclear Cells Transplantation in People With Sickle Cell Disease), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02448121 phase1 / phase2unknown statusnot on this map

Treatment for Hip, Knee, Ankle and Shoulder Osteonecrosis With Autologous Mononuclear Cells Transplantation in People With Sickle Cell Disease

TypeinterventionalSponsorFederal University of BahiaRan2006 to 2018Enrolled100ConditionsAvascular Necrosis of Bone, Sickle Cell DiseaseArmsAutologous bone marrow stem cell graft
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Gildasio DaltroProf. Edgar Santos Hospital Complex, Federal University of Bahia, R. Doutor Augusto Viana, s/n - Canela, Salvador, BA, 40110-060, Brazil.
Bruno Adelmo FrancoProf. Edgar Santos Hospital Complex, Federal University of Bahia, R. Doutor Augusto Viana, s/n - Canela, Salvador, BA, 40110-060, Brazil.
Thiago Batista FaleiroProf. Edgar Santos Hospital Complex, Federal University of Bahia, R. Doutor Augusto Viana, s/n - Canela, Salvador, BA, 40110-060, Brazil.
Davi Araujo Veiga RosárioProf. Edgar Santos Hospital Complex, Federal University of Bahia, R. Doutor Augusto Viana, s/n - Canela, Salvador, BA, 40110-060, Brazil.
Paula Braga DaltroHealth Science Institute, Federal University of Bahia, Av. Reitor Miguel Calmon, s/n, Vale do Canela, Salvador, BA, 40110-100, Brazil.
Roberto MeyerHealth Science Institute, Federal University of Bahia, Av. Reitor Miguel Calmon, s/n, Vale do Canela, Salvador, BA, 40110-100, Brazil.
Vitor FortunaHealth Science Institute, Federal University of Bahia, Av. Reitor Miguel Calmon, s/n, Vale do Canela, Salvador, BA, 40110-100, Brazil. vfort@ufba.br.
Universidade Federal da Bahia · BRComplexo Hospitalar Universitário Professor Edgard Santos · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe purpose of our study was to evaluate safety, feasibility and clinical results of bone marrow mononuclear cell (BMC) implantation for early-stage osteonecrosis of the knee (OK) secondary to sickle cell disease.

methodsThirty-three SCD patients (45 knees) with OK treated with BMC implantation in the osteonecrotic lesion were clinically and functionally evaluated through the American Knee Society Clinical Score (KSS), Knee Functional Score (KFS) and Numeric Rating Scale (NRS) pain score. MRI and radiographic examinations of the knee were assessed during a period of five years after intervention.

resultsNo complications or serious adverse event were associated with BMC implantation. From preoperative assessment to the latest follow-up, there was a significant (p < 0.001) improvement of clinical KSS (64.3 ± 9.7, range: 45-80 and 2.2 ± 4.1, range: 84-100, respectively), KFS (44.5 ± 8.0, range: 30-55 and 91.6 ± 5.8, range: 80-100, respectively) and reduction of NRS pain score (6.7 ± 1.2, range: 4-9 and 3.4 ± 1.0, range: 2-5, respectively). In total, 87% of patients (29/33) consistently experienced improvements in joint function and activity level as compared to preoperative score. No patient had additional surgery following BMC implantation. Radiographic assessment showed joint preservation and no progression to subchondral collapse at most recent follow-up.

conclusionsThe technique of BMC implantation is a promising, relatively simple and safe procedure for OK in SCD patients. Larger and long-term controlled trials are needed to support its clinical effectiveness.

trial registrationClinicalTrials.gov NCT02448121 . Retrospectively registered 19 May 2015.

Indexed as

AdolescentAdultAnemia, Sickle CellBone Marrow TransplantationFemaleHumansKnee JointMaleOsteonecrosisPilot ProjectsProspective StudiesTransplantation, AutologousYoung AdultAvascular necrosisCell implantationJoint preserving surgeryKneeOsteonecrosisSickle cell disease

Identifiers

PMID29788942
PMCPMC5964644
OpenAlexW2805827367

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.