Evidence map›Paper›PMID 29788938›Full record

SynthesisBMC pulmonary medicine2018

Symptom prevalence of patients with fibrotic interstitial lung disease: a systematic literature review.

Sabrina Carvajalino, Carla Reigada, Miriam J Johnson, Mendwas Dzingina, Sabrina Bajwah

Open access · goldAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC pulmonary medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 12 pooled it
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 12 syntheses or guidelines pooled it, 107 citations in OpenAlex.

  1. Pooled it
  2. Clinical care in interstitial lung disease: a critical appraisal of clinical guidance documents.European respiratory review : an official journal of the European Respiratory Society · 2025
    Pooled it
  3. Patient-reported outcome measures for cough used in interstitial lung disease: a systematic review.European respiratory review : an official journal of the European Respiratory Society · 2025
    Pooled it
  4. Guideline
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  6. Opioids for the palliation of symptoms in people with serious respiratory illness: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2024
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  12. The supportive care needs of people living with pulmonary fibrosis and their caregivers: a systematic review.European respiratory review : an official journal of the European Respiratory Society · 2020
    Pooled it
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1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Sabrina CarvajalinoFundación Santa Fé de Bogotá, Bogotá, Colombia.
Carla ReigadaHull York Medical School, Hertford Building, University of Hull, Hull, UK.
Miriam J JohnsonHull York Medical School, Hertford Building, University of Hull, Hull, UK.
Mendwas DzinginaCicely Saunders Institute, Bessemer Rd, London, UK.
Sabrina BajwahCicely Saunders Institute, Bessemer Rd, London, UK. sabrina.bajwah@kcl.ac.uk.ORCID http://orcid.org/0000-0001-5338-8107
Cicely Saunders International · GBUniversity of Hull · GBFundación Santa Fe de Bogotá · CO

Funding

Marie Curie MCCC-RP-15-A18859
6 · The paper itself

Abstract

backgroundThose affected by advanced fibrotic interstitial lung diseases have limited treatment options and in the terminal stages, the focus of care is on symptom management. However, quantitatively, little is known about symptom prevalence. We aimed to determine the prevalence of symptoms in Progressive Idiopathic Fibrotic Interstitial Lung Disease (PIF-ILD).

methodsSearches on eight electronic databases including MEDLINE for clinical studies between 1966 and 2015 where the target population was adults with PIF-ILD and for whom the prevalence of symptoms had been calculated.

resultsA total of 4086 titles were screened for eligibility criteria; 23 studies were included for analysis. The highest prevalence was that for breathlessness (54-98%) and cough (59-100%) followed by heartburn (25-65%) and depression (10-49%). The heterogeneity of studies limited their comparability, but many of the symptoms present in patients with other end-stage disease were also seen in PIF-ILD.

conclusionsThis is the first quantitative review of symptoms in people with Progressive Idiopathic Fibrotic Interstitial Lung Diseases. Symptoms are common, often multiple and have a comparable prevalence to those experienced in other advanced diseases. Quantification of these data provides valuable information to inform the allocation of resources.

Indexed as

CoughDepressionDyspneaHeartburnHumansLung Diseases, InterstitialPrevalenceSeverity of Illness IndexPulmonary fibrosisSymptom prevalence and interstitial lung disease

Identifiers

PMID29788938
PMCPMC5964639
OpenAlexW2807343737

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.