Evidence map›Paper›PMID 29788932›Full record

ReviewBMC pulmonary medicine2018

Geographic variation in the aetiology, epidemiology and microbiology of bronchiectasis.

Ravishankar Chandrasekaran, Micheál Mac Aogáin, James D Chalmers, Stuart J Elborn, Sanjay H Chotirmall

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in BMC pulmonary medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03809091 (Whole Genome Sequencing of Korean Patients With Idiopathic Bronchiectasis for Identification of Disease-Causing Variants), which is not on this map. Cited by 133 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
133citing papers in PubMed, 5 pooled it
15.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03809091 unknown statusnot on this mapstarted 2019, after this paper: background citation

Whole Genome Sequencing of Korean Patients With Idiopathic Bronchiectasis for Identification of Disease-Causing Variants

Typeobservational_patient_registrySponsorSeoul National University HospitalRan2019 to 2021Enrolled20ConditionsBronchiectasis Idiopathic, Cystic Fibrosis, Primary Ciliary DyskinesiaArmsWhole genome sequencing
3 · Its place in the literature

Who cites it

133 citing papers in PubMed, 5 syntheses or guidelines pooled it, 274 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Bronchiectasis in children: a systematic review of cytokine profile, immune cell phenotypes and microbiota in bronchoalveolar lavage fluid.European respiratory review : an official journal of the European Respiratory Society · 2026
    Pooled it
  4. Pooled it
  5. Pooled it
  6. Trial
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. The importance of symptoms in bronchiectasis.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  14. Article
  15. Article
  16. Article
  17. Antimicrobial resistance dynamics inBiochemistry and biophysics reports · 2026
    Article
  18. Review
  19. Article
  20. Article

73 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Ravishankar ChandrasekaranLee Kong Chian School of Medicine, Nanyang Technological University, Clinical Sciences Building, 11 Mandalay Road, Singapore, 308232, Singapore.
Micheál Mac AogáinLee Kong Chian School of Medicine, Nanyang Technological University, Clinical Sciences Building, 11 Mandalay Road, Singapore, 308232, Singapore.
James D ChalmersDivision of Molecular and Clinical Medicine, School of Medicine, Ninewells Hospital and Medical School, Dundee, UK.
Stuart J ElbornImperial College and Royal Brompton Hospital, London, UK.
Sanjay H ChotirmallLee Kong Chian School of Medicine, Nanyang Technological University, Clinical Sciences Building, 11 Mandalay Road, Singapore, 308232, Singapore. schotirmall@ntu.edu.sg.
Nanyang Technological University · SGNinewells Hospital · GBQueen's University Belfast · GB

Funding

Lee Kong Chian School of Medicine, Nanyang Technological University Start Up GrantNational Medical Research Council (SG) NMRC/TA/0048/2016
6 · The paper itself

Abstract

Bronchiectasis is a disease associated with chronic progressive and irreversible dilatation of the bronchi and is characterised by chronic infection and associated inflammation. The prevalence of bronchiectasis is age-related and there is some geographical variation in incidence, prevalence and clinical features. Most bronchiectasis is reported to be idiopathic however post-infectious aetiologies dominate across Asia especially secondary to tuberculosis. Most focus to date has been on the study of airway bacteria, both as colonisers and causes of exacerbations. Modern molecular technologies including next generation sequencing (NGS) have become invaluable tools to identify microorganisms directly from sputum and which are difficult to culture using traditional agar based methods. These have provided important insight into our understanding of emerging pathogens in the airways of people with bronchiectasis and the geographical differences that occur. The contribution of the lung microbiome, its ethnic variation, and subsequent roles in disease progression and response to therapy across geographic regions warrant further investigation. This review summarises the known geographical differences in the aetiology, epidemiology and microbiology of bronchiectasis. Further, we highlight the opportunities offered by emerging molecular technologies such as -omics to further dissect out important ethnic differences in the prognosis and management of bronchiectasis.

Indexed as

MicrobiotaAdultAgedBronchiectasisChildGeography, MedicalGlobal HealthHumansAspergillus spp.BronchiectasisFungiMicrobiomeMycobiomePseudomonas aeruginosa

Identifiers

PMID29788932
PMCPMC5964678
OpenAlexW2807413237

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.