ArticleBMC infectious diseases2018
Infection with high proportion of multidrug-resistant bacteria in conflict-related injuries is associated with poor outcomes and excess resource consumption: a cohort study of Syrian patients treated in Jordan.
Article in BMC infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02744144 (Wound Bacterial Microbiota and Their Antibiotic Resistance), which is not on this map. Cited by 25 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Wound Bacterial Microbiota and Their Antibiotic Resistance: a Prospective Cohort Study of Hospitalized Patients Originating From the Syrian Armed Conflict
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 72 citations in OpenAlex.
- Conflict-associated wounds and burns infected with GLASS pathogens in the Eastern Mediterranean Region: A systematic review.BMC infectious diseases · 2025Pooled it
- Antimicrobial resistance among GLASS pathogens in conflict and non-conflict affected settings in the Middle East: a systematic review.BMC infectious diseases · 2020Pooled it
- Cost analysis of negative-pressure wound therapy versus standard treatment of acute conflict-related extremity wounds within a randomized controlled trial.World journal of emergency surgery : WJES · 2022Trial
- Sliding osteotomy for reconstruction of short post-gunshot mandibular defects < 2 cm: a prospective case series and narrative literature review.BMC oral health · 2026Review
- War injuries and antimicrobial resistance: what impact do multi-resistant pathogens have on the treatment of Ukrainian war- wounded patients?European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026Article
- Formulation and Evaluation of Alginate-Based Hydrogel Membranes Loaded with Colistin for Effective Management of Multidrug-Resistant Wound Infections.Pharmaceutics · 2026Article
- Epidemiology of civilian patients with acute conflict-related extremity injuries sustained in Syria and Iraq.PLOS global public health · 2026Article
- Guest nation symposium: management of musculoskeletal war injuries.OTA international : the open access journal of orthopaedic trauma · 2025Article
- Antimicrobial resistance in a protracted war setting: a review of the literature from Palestine.mSystems · 2025Review
- Antibiotic resistance in the Middle East and Southern Asia: a systematic review and meta-analysis.JAC-antimicrobial resistance · 2025Review
- Bullet-related bacterial wound infections among injured personnel at emergency site hospitals in Bahir Dar: prevalence, antimicrobial susceptibility and associated factors.BMC microbiology · 2024Article
- Multidrug Resistance among Patients with Surgical Site Infection in a Tertiary Care Centre.JNMA; journal of the Nepal Medical Association · 2023Article
- Antimicrobial analysis of honey against Staphylococcus aureus isolates from wound, ADMET properties of its bioactive compounds and in-silico evaluation against dihydropteroate synthase.BMC complementary medicine and therapies · 2023Article
- Antibiotic resistance among bacteria isolated from war-wounded patients at the Weapon Traumatology Training Center of the International Committee of the Red Cross from 2016 to 2019: a secondary analysis of WHONET surveillance data.BMC infectious diseases · 2022Article
- Application of berberine-loaded albumin nanoparticles in infections of traumatic wounds.International journal of burns and trauma · 2022Article
- Article
- Challenges and opportunities for infection prevention and control in hospitals in conflict-affected settings: a qualitative study.Conflict and health · 2021Article
- Review
- The socioeconomic burden of antibiotic resistance in conflict-affected settings and refugee hosting countries: a systematic scoping review.Conflict and health · 2021Article
- Diabetic foot infections: Profile and antibiotic susceptibility patterns of bacterial isolates in a tertiary care hospital of Oman.Journal of education and health promotion · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundArmed conflicts are a major contributor to injury and death globally. Conflict-related injuries are associated with a high risk of wound infection, but it is unknown to what extent infection directly relates to sustainment of life and restoration of function. The aim of this study was to investigate the outcome and resource consumption among civilians receiving acute surgical treatment due to conflict-related injuries. Patients with and without wound infections were compared.
methodsWe performed a cohort study using routinely collected data from 457 consecutive Syrian civilians that received surgical treatment for acute conflict-related injuries during 2014-2016 at a Jordanian hospital supported by Médecins Sans Frontières. We defined wound infection as clinical signs of infection verified by a positive culture. We used logistic regression models to evaluate infection-related differences in outcome and resource consumption.
resultsWound infection was verified in 49/457 (11%) patients. Multidrug-resistance (MDR) was detected in 36/49 (73%) of patients with infection. Among patients with infection, 11/49 (22%) were amputated, compared to 37/408 (9%) without infection, crude relative risk = 2.62 (95% confidence interval 1.42-4.81). Infected patients needed 12 surgeries on average, compared to five in non-infected patients (p < .00001). Mean length of stay was 77 days for patients with infection, and 35 days for patients without infection (p = .000001).
conclusionsAmong Syrian civilians, infected conflict-related wounds had a high prevalence of MDR bacteria. Wound infection was associated with poor outcomes and high resource consumption. These results could guide the development of antibiotic protocols and adaptations of surgical management to improve care for wound infections in conflict-related injuries.
trial registrationClinicalTrials.gov ( NCT02744144 ). Registered April 13, 2016. Retrospectively registered.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.