Evidence map›Paper›PMID 29788499›Full record

ArticleNucleic acids research2018

Group I introns are widespread in archaea.

Eric P Nawrocki, Thomas A Jones, Sean R Eddy

Open access · goldAbstract read
In one paragraph

Article in Nucleic acids research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
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  11. The discovery ofiScience · 2024
    Article
  12. The co-dispersal strategy ofMycoscience · 2024
    Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Shared properties and singularities of exoribonuclease-resistant RNAs in viruses.Computational and structural biotechnology journal · 2021
    Review
  18. Article
  19. Archaeal transcription.Transcription · 2020
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Eric P NawrockiNational Center for Biotechnology Information, U.S. National Library of Medicine, Bethesda, MD 20894, USA.
Thomas A JonesHoward Hughes Medical Institute, Harvard University, Cambridge, USA.
Sean R EddyHoward Hughes Medical Institute, Harvard University, Cambridge, USA.
Howard Hughes Medical Institute · USNational Center for Biotechnology Information · US

Funding

HMMER and Infernal: Finding distant homologs of sequences and RNA structuresR01HG009116 · NHGRI · HARVARD UNIVERSITY · PI EDDY, SEAN R · 2016 to 2025
$4.3M
NHGRI NIH HHS R01 HG009116
6 · The paper itself

Abstract

Group I catalytic introns have been found in bacterial, viral, organellar, and some eukaryotic genomes, but not in archaea. All known archaeal introns are bulge-helix-bulge (BHB) introns, with the exception of a few group II introns. It has been proposed that BHB introns arose from extinct group I intron ancestors, much like eukaryotic spliceosomal introns are thought to have descended from group II introns. However, group I introns have little sequence conservation, making them difficult to detect with standard sequence similarity searches. Taking advantage of recent improvements in a computational homology search method that accounts for both conserved sequence and RNA secondary structure, we have identified 39 group I introns in a wide range of archaeal phyla, including examples of group I introns and BHB introns in the same host gene.

Indexed as

ArchaeaBase SequenceIntronsNucleic Acid ConformationPhylogenyRNA, ArchaealRNA, CatalyticSpecies SpecificityRNA, ArchaealRNA, Catalytic

Identifiers

PMID29788499
PMCPMC6125680
OpenAlexW2803631852

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.