ArticleGigaScience2018
Molecular modularity and asymmetry of the molluscan mantle revealed by a gene expression atlas.
Article in GigaScience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- The Gln-rich protein twip1 promotes high-density {110} twins formation in the shell of the limpetProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Molluscan Shells, Spicules, and Gladii Are Evolutionarily Deeply Conserved.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2025Article
- The genome of the simultaneously hermaphroditic snail Lymnaea stagnalis reveals an evolutionary expansion of FMRFamide-like receptors.Scientific reports · 2024Article
- The adult shell matrix protein repertoire of the marine snail Crepidula is dominated by conserved genes that are also expressed in larvae.BMC ecology and evolution · 2024Article
- Diverting the Use of Hand-Operated Tablet Press Machines to Bioassays: A Novel Protocol to Test 'Waste' Insoluble Shell Matrices.Methods and protocols · 2024Article
- Cell type and gene regulatory network approaches in the evolution of spiralian biomineralisation.Briefings in functional genomics · 2023Review
- Evolutionary conservation and divergence of the transcriptional regulation of bivalve shell secretion across life-history stages.Royal Society open science · 2022Article
- Heme-Peroxidase 2 Modulated by POU2F1 and SOX5 is Involved in Pigmentation in Pacific Oyster (Crassostrea gigas).Marine biotechnology (New York, N.Y.) · 2022Article
- Biomineralization: Integrating mechanism and evolutionary history.Science advances · 2022Review
- Evolutionary modularity, integration and disparity in an accretionary skeleton: analysis of venerid Bivalvia.Proceedings. Biological sciences · 2022Article
- Transcriptomic analysis of shell repair and biomineralization in the blue mussel, Mytilus edulis.BMC genomics · 2021Article
- Mobilizing molluscan models and genomes in biology.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Article
- Mantle Modularity Underlies the Plasticity of the Molluscan Shell: Supporting Data FromFrontiers in genetics · 2021Article
- The pond snail Lymnaea stagnalis.EvoDevo · 2020Review
- Intracellular pH regulation in mantle epithelial cells of the Pacific oyster, Crassostrea gigas.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2020Article
- Functional shell matrix proteins tentatively identified by asymmetric snail shell morphology.Scientific reports · 2020Article
- Molecular mechanisms of biomineralization in marine invertebrates.The Journal of experimental biology · 2020Review
- Computationally predicted gene regulatory networks in molluscan biomineralization identify extracellular matrix production and ion transportation pathways.Bioinformatics (Oxford, England) · 2020Article
- Learning from beautiful monsters: phylogenetic and morphogenetic implications of left-right asymmetry in ammonoid shells.BMC evolutionary biology · 2019Article
- Mantle transcriptome sequencing ofPeerJ · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Conchiferan molluscs construct a biocalcified shell that likely supported much of their evolutionary success. However, beyond broad proteomic and transcriptomic surveys of molluscan shells and the shell-forming mantle tissue, little is known of the spatial and ontogenetic regulation of shell fabrication. In addition, most efforts have been focused on species that deposit nacre, which is at odds with the majority of conchiferan species that fabricate shells using a crossed-lamellar microstructure, sensu lato. Results: By combining proteomic and transcriptomic sequencing with in situ hybridization we have identified a suite of gene products associated with the production of the crossed-lamellar shell in Lymnaea stagnalis. With this spatial expression data we are able to generate novel hypotheses of how the adult mantle tissue coordinates the deposition of the calcified shell. These hypotheses include functional roles for unusual and otherwise difficult-to-study proteins such as those containing repetitive low-complexity domains. The spatial expression readouts of shell-forming genes also reveal cryptic patterns of asymmetry and modularity in the shell-forming cells of larvae and adult mantle tissue. Conclusions: This molecular modularity of the shell-forming mantle tissue hints at intimate associations between structure, function, and evolvability and may provide an elegant explanation for the evolutionary success of the second largest phylum among the Metazoa.
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