Evidence map›Paper›PMID 29788246›Full record

ReviewAmerican journal of hypertension2018

Hypertension Induced Morphological and Physiological Changes in Cells of the Arterial Wall.

Patricia Martinez-Quinones, Cameron G McCarthy, Stephanie W Watts, Nicole S Klee, Amel Komic, Fabiano B Calmasini, Fernanda Priviero, Alexander Warner, Yu Chenghao, Camilla F Wenceslau

Open access · bronzeAbstract readReview
In one paragraph

Review in American journal of hypertension, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 104 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Hypertension: a missing piece in HFpEF?Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Review
  4. Review
  5. Review
  6. Article
  7. Observational
  8. Article
  9. Article
  10. Review
  11. Observational
  12. Article
  13. Article
  14. Article
  15. Epidural hematoma secondary to a ruptured occipital artery.Surgical neurology international · 2026
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Circulating Extracellular Vesicles in Cardiovascular Disease.International journal of molecular sciences · 2025
    Review

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Patricia Martinez-QuinonesDepartment of Surgery, Medical College of Georgia at Augusta University, Augusta, Georgia.
Cameron G McCarthyDepartment of Physiology, Medical College of Georgia at Augusta University, Augusta, Georgia.
Stephanie W WattsDepartment of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan, USA.
Nicole S KleeDepartment of Physiology, Medical College of Georgia at Augusta University, Augusta, Georgia.
Amel KomicDepartment of Surgery, Medical College of Georgia at Augusta University, Augusta, Georgia.
Fabiano B CalmasiniDepartment of Physiology, Medical College of Georgia at Augusta University, Augusta, Georgia.
Fernanda PrivieroDepartment of Physiology, Medical College of Georgia at Augusta University, Augusta, Georgia.
Alexander WarnerDepartment of Physiology, Medical College of Georgia at Augusta University, Augusta, Georgia.
Yu ChenghaoDepartment of Physiology, Medical College of Georgia at Augusta University, Augusta, Georgia.
Camilla F WenceslauDepartment of Physiology, Medical College of Georgia at Augusta University, Augusta, Georgia.
Augusta University · USMichigan State University · US

Funding

Toll-like receptor 9 activation by mitochondrial DNA causes vascular injury in hypertensionP01HL134604 · NHLBI · AUGUSTA UNIVERSITY · PI O'CONNOR, PAUL MICHAEL · 2017 to 2021
$9.4M
Intrarenal Arteries Sense Trauma-derived Mitochondrial N-formyl Peptides Leading to Kidney Injury in SIRSK99GM118885 · NIGMS · AUGUSTA UNIVERSITY · PI WENCESLAU, CAMILLA FERREIRA · 2016 to 2017
$162k
NHLBI NIH HHS P01 HL134604NIGMS NIH HHS K99 GM118885
6 · The paper itself

Abstract

Morphological and physiological changes in the vasculature have been described in the evolution and maintenance of hypertension. Hypertension-induced vascular dysfunction may present itself as a contributing, or consequential factor, to vascular remodeling caused by chronically elevated systemic arterial blood pressure. Changes in all vessel layers, from the endothelium to the perivascular adipose tissue (PVAT), have been described. This mini-review focuses on the current knowledge of the structure and function of the vessel layers, specifically muscular arteries: intima, media, adventitia, PVAT, and the cell types harbored within each vessel layer. The contributions of each cell type to vessel homeostasis and pathophysiological development of hypertension will be highlighted.

Indexed as

Arterial PressureVascular RemodelingAdipose TissueAnimalsArteriesHumansHypertensionTunica IntimaTunica Media

Identifiers

PMID29788246
PMCPMC6132119
OpenAlexW2804756360

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.