Evidence map›Paper›PMID 29788225›Full record

ArticleDatabase : the journal of biological databases and curation2018

LnChrom: a resource of experimentally validated lncRNA-chromatin interactions in human and mouse.

Fulong Yu, Guanxiong Zhang, Aiai Shi, Jing Hu, Feng Li, Xinxin Zhang, Yan Zhang, Jian Huang, Yun Xiao, Xia Li and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Database : the journal of biological databases and curation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 38 citations in OpenAlex.

  1. Review
  2. Article
  3. RNA-Chrom: a manually curated analytical database of RNA-chromatin interactome.Database : the journal of biological databases and curation · 2023
    Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Decoding LncRNAs.Cancers · 2021
    Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. GREG-studying transcriptional regulation using integrative graph databases.Database : the journal of biological databases and curation · 2020
    Article
  19. Exosome-Derived LncRNAs in Lung Cancer.Frontiers in oncology · 2020
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Fulong YuCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, China.
Guanxiong ZhangCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, China.
Aiai ShiCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, China.
Jing HuCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, China.
Feng LiCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, China.
Xinxin ZhangCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, China.
Yan ZhangCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, China.
Jian HuangCenter for Informational Biology, University of Electronic Science and Technology of China, Chengdu 611731, China.
Yun XiaoCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, China.
Xia LiCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, China.
Shujun ChengCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, China.
Harbin Medical University · CNUniversity of Electronic Science and Technology of China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long non-coding RNAs (lncRNAs) constitute an important layer of chromatin regulation that contributes to various biological processes and diseases. By interacting with chromatin, many lncRNAs can regulate that state of chromatin by recruiting chromatin-modifying complexes and thus control large-scale gene expression programs. However, the available information on interactions between lncRNAs and chromatin is hidden in a large amount of dispersed literature and has not been extensively collected. We established the LnChrom database, a manually curated resource of experimentally validated lncRNA-chromatin interactions. The current release of LnChrom includes 382 743 interactions in human and mouse. We also manually collected detailed metadata for each interaction pair, including those of chromatin modifying factors, epigenetic marks and disease associations. LnChrom provides a user-friendly interface to facilitate browsing, searching and retrieving of lncRNA-chromatin interaction data. Additionally, a large amount of multi-omics data was integrated into LnChrom to aid in characterizing the effects of lncRNA-chromatin interactions on epigenetic modifications and transcriptional expression. We believe that LnChrom is a timely and valuable resource that can greatly motivate mechanistic research into lncRNAs.Database URL: http://biocc.hrbmu.edu.cn/LnChrom/.

Indexed as

ChromatinDatabases, Nucleic AcidEpigenesis, GeneticMetadataRNA, Long NoncodingTranscription, GeneticAnimalsHumansMiceChromatinRNA, Long Noncoding

Identifiers

PMID29788225
PMCPMC5960994
OpenAlexW2806466286

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.