ArticlePloS one2018
Endocrine disrupting potency of organic pollutant mixtures isolated from commercial fish oil evaluated in yeast-based bioassays.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 14 citations in OpenAlex.
- Modern Carbon-Based Materials for Adsorptive Removal of Organic and Inorganic Pollutants from Water and Wastewater.Molecules (Basel, Switzerland) · 2021Review
- Histological Evaluation of Gonad Impairments in Russian Sturgeon (Animals : an open access journal from MDPI · 2020Article
- Yeast-Based Biosensors: Current Applications and New Developments.Biosensors · 2020Review
- Overview of the effects of chemical mixtures with endocrine disrupting activity in the context of real-life risk simulation: An integrative approach (Review).World Academy of Sciences journal · 2019Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this work was to evaluate the activity of xenobiotic mixtures containing persistent organic pollutants isolated from commercial fish oil samples against sex hormone receptors, including estrogen and androgen. The applied bioassay was based on transgenic yeast strains. The mixtures were extracted from the samples using the semi-permeable membrane dialysis technique and analyzed with gas chromatography/ion trap mass spectrometry. It turned out that mixtures of chemicals isolated from fish oil may interact with human steroid sex hormone receptors in various ways: the tested samples showed both estrogenic and anti-androgenic activity. Calculated 17β-estradiol equivalents for the tested samples ranged between 0.003 and 0.073 pg g-1 (fat). Anti-androgenic activity expressed as the flutamide equivalent concentration was in the 18.58-216.21 ng g-1 (fat) range. Polychlorinated biphenyls and various DDT metabolites were the main fish oil pollutants influencing the receptors. Additivity and/or synergy between chemicals was observed in the ER/AR mediated response.
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Registered trials
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