ArticleAmerican journal of respiratory and critical care medicine2018
Deterioration of Regional Lung Strain and Inflammation during Early Lung Injury.
Article in American journal of respiratory and critical care medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.
- Optimized ventilation strategy for surgery on patients with obesity from the perspective of lung protection: A network meta-analysis.Frontiers in immunology · 2022Pooled it
- Individualized PEEP to optimise respiratory mechanics during abdominal surgery: a pilot randomised controlled trial.British journal of anaesthesia · 2020Trial
- Obesity: biomechanical implications for mechanical ventilation.Critical care (London, England) · 2026Review
- Idiopathic pulmonary fibrosis from a multiscale mechanobiology perspective: Mechanisms and future therapeutic prospects.iScience · 2026Review
- Imaging in animal models: bridging experimental findings and human pathophysiology.Critical care (London, England) · 2025Review
- Ventilator-Induced Lung Injury: The Unseen Challenge in Acute Respiratory Distress Syndrome Management.Journal of clinical medicine · 2025Review
- Perfusion deficits may underlie lung and kidney injury in severe COVID-19 disease: insights from a multicenter international cohort study.Journal of anesthesia, analgesia and critical care · 2024Review
- Imaging the pulmonary vasculature in acute respiratory distress syndrome.Nitric oxide : biology and chemistry · 2024Review
- Dynamic relative regional lung strain estimated by computed tomography and electrical impedance tomography in ARDS patients.Critical care (London, England) · 2023Article
- Pronation Reveals a Heterogeneous Response of Global and Regional Respiratory Mechanics in Patients With Acute Hypoxemic Respiratory Failure.Critical care explorations · 2023Article
- Dynamic lung aeration and strain with positive end-expiratory pressure individualized to maximal compliance versus ARDSNet low-stretch strategy: a study in a surfactant depletion model of lung injury.Critical care (London, England) · 2023Article
- Worsening of lung perfusion to tissue density distributions during early acute lung injury.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Quantitative Imaging Metrics for the Assessment of Pulmonary Pathophysiology: An Official American Thoracic Society and Fleischner Society Joint Workshop Report.Annals of the American Thoracic Society · 2023Article
- Molecular imaging of inflammation with PET in acute and ventilator-induced lung injury.Frontiers in physiology · 2023Review
- Perfusion imaging heterogeneity during NO inhalation distinguishes pulmonary arterial hypertension (PAH) from healthy subjects and has potential as an imaging biomarker.Respiratory research · 2022Article
- Intraoperative Protective Mechanical Ventilation: Fact or Fiction?Anesthesiology · 2022Article
- Imaging the acute respiratory distress syndrome: past, present and future.Intensive care medicine · 2022Review
- Lung response to prone positioning in mechanically-ventilated patients with COVID-19.Critical care (London, England) · 2022Article
- The association between regional transcriptome profiles and lung volumes in response to mechanical ventilation and lung injury.Respiratory research · 2022Article
- Distribution and Magnitude of Regional Volumetric Lung Strain and Its Modification by PEEP in Healthy Anesthetized and Mechanically Ventilated Dogs.Frontiers in veterinary science · 2022Article
Corrections and comments
- Commented on by
Authors and funding
12 authors at 6 institutions in 4 countries.
Funding
Abstract
rationaleThe contribution of aeration heterogeneity to lung injury during early mechanical ventilation of uninjured lungs is unknown.
objectivesTo test the hypotheses that a strategy consistent with clinical practice does not protect from worsening in lung strains during the first 24 hours of ventilation of initially normal lungs exposed to mild systemic endotoxemia in supine versus prone position, and that local neutrophilic inflammation is associated with local strain and blood volume at global strains below a proposed injurious threshold.
methodsVoxel-level aeration and tidal strain were assessed by computed tomography in sheep ventilated with low Vt and positive end-expiratory pressure while receiving intravenous endotoxin. Regional inflammation and blood volume were estimated from 2-deoxy-2-[(18)F]fluoro-d-glucose ( MEASUREMENTS AND MAIN
resultsSpatial heterogeneity of aeration and strain increased only in supine lungs (P < 0.001), with higher strains and atelectasis than prone at 24 hours. Absolute strains were lower than those considered globally injurious. Strains redistributed to higher aeration areas as lung injury progressed in supine lungs. At 24 hours, tissue-normalized
conclusionsMechanical ventilation consistent with clinical practice did not generate excessive regional strain in heterogeneously aerated supine lungs. However, it allowed worsening of spatial strain distribution in these lungs, associated with increased inflammation. Our results support the implementation of early aeration homogenization in normal lungs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.