Evidence map›Paper›PMID 29786885›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2018

Automated Buildup of Biomimetic Films in Cell Culture Microplates for High-Throughput Screening of Cellular Behaviors.

Paul Machillot, Catarina Quintal, Fabien Dalonneau, Loic Hermant, Pauline Monnot, Kelsey Matthews, Vincent Fitzpatrick, Jie Liu, Isabelle Pignot-Paintrand, Catherine Picart

Open access · greenAbstract read
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 43 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Paul MachillotGrenoble Institute of Technology, Université Grenoble Alpes, 38000, Grenoble, France.
Catarina QuintalGrenoble Institute of Technology, Université Grenoble Alpes, 38000, Grenoble, France.
Fabien DalonneauGrenoble Institute of Technology, Université Grenoble Alpes, 38000, Grenoble, France.
Loic HermantGrenoble Institute of Technology, Université Grenoble Alpes, 38000, Grenoble, France.
Pauline MonnotGrenoble Institute of Technology, Université Grenoble Alpes, 38000, Grenoble, France.
Kelsey MatthewsGrenoble Institute of Technology, Université Grenoble Alpes, 38000, Grenoble, France.
Vincent FitzpatrickGrenoble Institute of Technology, Université Grenoble Alpes, 38000, Grenoble, France.
Jie LiuGrenoble Institute of Technology, Université Grenoble Alpes, 38000, Grenoble, France.
Isabelle Pignot-PaintrandGrenoble Institute of Technology, Université Grenoble Alpes, 38000, Grenoble, France.
Catherine PicartGrenoble Institute of Technology, Université Grenoble Alpes, 38000, Grenoble, France.ORCID http://orcid.org/0000-0003-0130-1000
Institut polytechnique de Grenoble · FR

Funding

European Research Council 259370
6 · The paper itself

Abstract

An automatic method is established for layer-by-layer (LbL) assembly of biomimetic coatings in cell culture microplates using a commercial liquid-handling robot. Highly homogeneous thin films are formed at the bottom of each microwell. The LbL film-coated microplates are compatible with common cellular assays, using microplate readers and automated microscopes. Cellular adhesion is screened on crosslinked and peptide-functionalized LbL films and stem cell differentiation in response to increasing doses of bone morphogenetic proteins (2, 4, 7, 9). This method paves the way for future applications of LbL films in cell-based assays for regenerative medicine and high-throughput drug screening.

Indexed as

BiomimeticsCell Differentiationautomationcell culture platehigh content screeninglayer-by-layer assemblyreproducibilityrobot

Identifiers

PMID29786885
PMCPMC6701983
OpenAlexW2803813941

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.