Evidence map›Paper›PMID 29786674›Full record

ArticleNutrients2018

Choline Supplementation Prevents a Hallmark Disturbance of Kwashiorkor in Weanling Mice Fed a Maize Vegetable Diet: Hepatic Steatosis of Undernutrition.

Thaddaeus May, Kevin C Klatt, Jacob Smith, Eumenia Castro, Mark Manary, Marie A Caudill, Farook Jahoor, Marta L Fiorotto

Open access · goldAbstract readComparative Study
In one paragraph

Article in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Thaddaeus MayChildrens' Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, 1100 Bates Street, Houston, TX 77030, USA. maythaddaeus@gmail.com.
Kevin C KlattDivision of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA. kck731@gmail.com.
Jacob SmithUniversity of Texas Rio Grande Valley School of Medicine, 1210 West Schunior Street, Edinburg, TX 78541, USA. jacob.smith01@utrgv.edu.
Eumenia CastroChildrens' Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, 1100 Bates Street, Houston, TX 77030, USA. ecastro@bcm.edu.
Mark ManaryDepartment of Pediatrics, Washington University in St. Louis School of Medicine, 660 S. Euclid Ave., St. Louis, MO 63110, USA. manary@kids.wustl.edu.
Marie A CaudillDivision of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA. mac379@cornell.edu.
Farook JahoorChildrens' Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, 1100 Bates Street, Houston, TX 77030, USA. fjahoor@bcm.edu.
Marta L FiorottoChildrens' Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, 1100 Bates Street, Houston, TX 77030, USA. martaf@bcm.edu.ORCID 0000-0001-8475-4704
Children's Nutrition Research Center at Baylor College of Medicine · USCornell University · USThe University of Texas Rio Grande Valley · USWashington University in St. Louis · US

Funding

Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI DAVID R ROWLEY · 2007 to 2026
$73.9M
Tissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Geoffrey A Preidis · 2001 to 2026
$28.3M
TRAINING IN MATERNAL AND CHILD NUTRITIONT32HD087137 · NICHD · CORNELL UNIVERSITY · PI Laura Bellows, Julia L. Finkelstein · 2016 to 2026
$2.0M
The Childrens Nutrition Research Center Training ProgramT32HD071839 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI HAYMOND, MOREY W · 2012 to 2016
$906k
NCI NIH HHS P30 CA125123NICHD NIH HHS T32 HD071839NICHD NIH HHS T32 HD087137NIDDK NIH HHS P30 DK056338
6 · The paper itself

Abstract

Hepatic steatosis is a hallmark feature of kwashiorkor malnutrition. However, the pathogenesis of hepatic steatosis in kwashiorkor is uncertain. Our objective was to develop a mouse model of childhood undernutrition in order to test the hypothesis that feeding a maize vegetable diet (MVD), like that consumed by children at risk for kwashiorkor, will cause hepatic steatosis which is prevented by supplementation with choline. A MVD was developed with locally sourced organic ingredients, and fed to weanling mice (

Indexed as

Dietary SupplementsZea maysAnimal FeedAnimal Nutritional Physiological PhenomenaAnimalsCholineDisease Models, AnimalEatingEnergy MetabolismFatty LiverFemaleGene Expression RegulationKwashiorkorLipid MetabolismLiverMaleCholinebetainecholinefatty liver diseasehepatic steatosiskwashiorkormalnutritionmethioninemethylationone carbon metabolismtrimethylamine N-oxide (TMAO)

Identifiers

PMID29786674
PMCPMC5986532
OpenAlexW2803747006

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.