Evidence map›Paper›PMID 29786668›Full record

ArticleInternational journal of molecular sciences2018

SCF/c-KIT Signaling Increased Mucin2 Production by Maintaining Atoh1 Expression in Mucinous Colorectal Adenocarcinoma.

Ping Shen, Shu Yang, Haimei Sun, Guilan Li, Bo Wu, Fengqing Ji, Tingyi Sun, Deshan Zhou

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Combinatorial chemistry & high throughput screening · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Ping ShenDepartment of Histology and Embryology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China. shenping2014@sina.com.
Shu YangDepartment of Histology and Embryology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China. yangshu@ccmu.edu.cn.
Haimei SunDepartment of Histology and Embryology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China. haimei@ccmu.edu.cn.
Guilan LiDepartment of Histology and Embryology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China. lancylee222@163.com.
Bo WuDepartment of Histology and Embryology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China. wubo2007@ccmu.edu.cn.
Fengqing JiDepartment of Histology and Embryology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China. jfq@ccmu.edu.cn.
Tingyi SunDepartment of Histology and Embryology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China. styj211@ccmu.edu.cn.ORCID 0000-0003-4448-6340
Deshan ZhouDepartment of Histology and Embryology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China. zhouds08@ccmu.edu.cn.
Capital Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mucinous colorectal adenocarcinoma (MCA) patients often a show high risk of malignant potential and a poorer survival rate. Given that the pathological feature and oncobiological characteristics of MCA are correlated with its abundant extracellular mucin2 (MUC2), we paid interest toward investigating the key factor that promotes MUC2 production exposure to highly-activated stem cell factor (SCF)/c-KIT signaling, which we believed to contribute to MCA formation. Long-term azoxymethane and dextran sodium sulfate treatment successfully induced MCA only in wild-type (WT) mice at week 37 and 43, while all

Indexed as

Signal TransductionAdenocarcinoma, MucinousAnimalsBasic Helix-Loop-Helix ProteinsCell Line, TumorColorectal NeoplasmsHumansMiceMice, Inbred C57BLMucin-2Proto-Oncogene Proteins c-kitStem Cell FactorBasic Helix-Loop-Helix ProteinsMucin-2Proto-Oncogene Proteins c-kitStem Cell FactorAtonal homologue 1 (Atoh1)c-KITcolorectal cancerMucin2mucinous colorectal adenocarcinoma

Identifiers

PMID29786668
PMCPMC5983812
OpenAlexW2804654288

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.