Evidence map›Paper›PMID 29786547›Full record

ArticleThorax2018

Protective effect of breastfeeding on recurrent cough in adulthood.

Kimberly D Gerhart, Debra A Stern, Stefano Guerra, Wayne J Morgan, Fernando D Martinez, Anne L Wright

Abstract read
In one paragraph

Article in Thorax, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Non-atopic rhinitis at age 6 is associated with subsequent development of asthma.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2019
    Trial
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Kimberly D GerhartAsthma and Airway Disease Research Center UAHS, University of Arizona, Tucson, Arizona, USA.
Debra A Stern
Stefano GuerraAsthma and Airway Disease Research Center UAHS, University of Arizona, Tucson, Arizona, USA.
Wayne J MorganAsthma and Airway Disease Research Center UAHS, University of Arizona, Tucson, Arizona, USA.
Fernando D MartinezAsthma and Airway Disease Research Center UAHS, University of Arizona, Tucson, Arizona, USA.
Anne L WrightAsthma and Airway Disease Research Center UAHS, University of Arizona, Tucson, Arizona, USA.

Funding

Early Origins of Chronic Lung Disease: Outcomes into the Fifth Decade of LifeR01HL132523 · NHLBI · UNIVERSITY OF ARIZONA · PI Stefano Guerra, Fernando D Martinez · 2016 to 2026
$15.1M
Natural History of Asthma from Birth to Early Adult LifeR01HL056177 · NHLBI · UNIVERSITY OF ARIZONA · PI GUERRA, STEFANO, MARTINEZ, FERNANDO D · 1996 to 2015
$14.4M
NHLBI NIH HHS R01 HL056177NHLBI NIH HHS R01 HL132523
6 · The paper itself

Abstract

rationaleBreastfeeding protects from respiratory infections in early life but its relationship to recurrent cough and other respiratory outcomes in adult life is not well established.

methodsInfant feeding practices were assessed prospectively in the Tucson Children's Respiratory Study, a non-selected birth cohort and categorised into formula from birth or introduced <1 month, formula introduced ≥1 to <4 months and exclusive breastfeeding for ≥4 months. Infant feeding was assessed as an ordinal variable representing an increasing dose of breastmilk across the three categories.

resultsOf the 786 participants, 19% breastfed <1 month, 50% breastfed ≥1 to <4 months and 31% breastfed ≥4 months. The prevalence of recurrent cough at 22, 26 and 32 years was 17%, 15% and 16%, respectively. Each ordinal increase in breastfeeding duration was associated with a decreased risk of recurrent cough in adult life: adjusted OR=0.71, (95% CI: 0.56 to 0.89), p=0.004. Additional adjustment for concurrent adult asthma, wheeze, smoking and lung volume did not change these results.

conclusionLonger duration of breastfeeding reduces the risk of recurrent cough in adult life, regardless of smoking and other respiratory symptoms, suggesting long-term protective effects on respiratory health.

Indexed as

Breast FeedingAdultCohort StudiesCoughFemaleHumansInfantInfant, NewbornMaleRecurrenceTime FactorsYoung Adultasthmacough/mechanisms/pharmacology

Identifiers

PMID29786547
PMCPMC6473807

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.