ArticleJournal of neurotrauma2019
Orthopedic Injured versus Uninjured Comparison Groups for Neuroimaging Research in Mild Traumatic Brain Injury.
Article in Journal of neurotrauma, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 4 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Using neuroimaging to identify sex differences in adults with sports-related concussion: a systematic review.Brain imaging and behavior · 2025Pooled it
- Diffusion-Weighted Imaging in Mild Traumatic Brain Injury: A Systematic Review of the Literature.Neuropsychology review · 2023Pooled it
- Challenges and opportunities for neuroimaging in young patients with traumatic brain injury: a coordinated effort towards advancing discovery from the ENIGMA pediatric moderate/severe TBI group.Brain imaging and behavior · 2021Pooled it
- The second decade of DTI in TBI part 1: a systematic review of mild TBI.Frontiers in neurologyPooled it
- Associations between psychological resilience and metrics of white matter microstructure in pediatric concussion.Human brain mapping · 2023Trial
- Investigating acute-to-subacute neuroanatomical outcomes and the role of sex and age in adolescent concussion: A PedCARE+MRI substudy.Neuroimage. Reports · 2026Article
- Thalamocortical white matter microstructure and cognition following mild traumatic brain injury: A fixel-based analysis.Brain structure & function · 2026Article
- Neuronal and glial networks interact with traumatic brain injury to modulate cognition in ABCD study.NPJ systems biology and applications · 2026Article
- Differential effects of sport type on brain versus orthopedic injury and sports benefits in the adolescent brain cognitive development study.Brain injury · 2025Article
- Longitudinal neurocognitive outcomes in children with mild traumatic brain injury: An ABCD cohort analysis.Journal of the International Neuropsychological Society : JINS · 2025Article
- Unveiling the predictive power of biomarkers in traumatic brain injury: A narrative review focused on clinical outcomes.Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia · 2025Review
- Regional and Global Changes in Brain Structure 1-Year Post Pediatric "Mild" Traumatic Brain Injury.Annals of neurology · 2025Article
- Review
- Observational
- Quality of Life in Youth Soccer Players After Mild Traumatic Brain Injury.Journal of athletic training · 2024Article
- Cognition and post-concussive symptom status after pediatric mild traumatic brain injury.Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence · 2024Article
- Knowledge and attitudes toward mild traumatic brain injury among patients and family members.Frontiers in public health · 2024Article
- Assessment of white matter microstructure integrity in subacute postconcussive vestibular dysfunction using NODDI.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Investigating cognitive reserve, symptom resolution and brain connectivity in mild traumatic brain injury.BMC neurology · 2023Observational
- Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
To address controversy surrounding the most appropriate comparison group for mild traumatic brain injury (mTBI) research, mTBI patients 12-30 years of age were compared with an extracranial orthopedic injury (OI) patient group and an uninjured, typically developing (TD) participant group with comparable demographic backgrounds. Injured participants underwent subacute (within 96 h) and late (3 months) diffusion tensor imaging (DTI); TD controls underwent DTI once. Group differences in fractional anisotropy (FA) and mean diffusivity (MD) of commonly studied white matter tracts were assessed. For FA, subacute group differences occurred in the bilateral inferior frontal occipital fasciculus (IFOF) and right inferior longitudinal fasciculus (ILF), and for MD, differences were found in the total corpus callosum, right uncinate fasciculus, IFOF, ILF, and bilateral cingulum bundle (CB). In these analyses, differences (lower FA and higher MD) were generally observed between the mTBI and TD groups but not between the mTBI and OI groups. After a 3 month interval, groups significantly differed in left IFOF FA and in right IFOF and CB MD; the TD group had significantly higher FA and lower MD than both injury groups, which did not differ. There was one exception to this pattern, in which the OI group demonstrated significantly lower FA in the left ILF than the TD group, although neither group differed from the mTBI group. The mTBI and OI groups had generally similar longitudinal results. Findings suggest that different conclusions about group-level DTI analyses could be drawn, depending on the selected comparison group, highlighting the need for additional research in this area. Where possible, mTBI studies may benefit from the inclusion of both OI and TD controls.
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