Evidence map›Paper›PMID 29786465›Full record

Trial reportJournal of neurotrauma2018

Trunk Stability Enabled by Noninvasive Spinal Electrical Stimulation after Spinal Cord Injury.

Mrinal Rath, Albert H Vette, Shyamsundar Ramasubramaniam, Kun Li, Joel Burdick, Victor R Edgerton, Yury P Gerasimenko, Dimitry G Sayenko

Registry-linked trialAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of neurotrauma, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04807764 (Priming With High-Frequency Trans-spinal Stimulation to Augment Locomotor Benefits in Spinal Cord Injury), which is not on this map. Cited by 97 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
97citing papers in PubMed, 6 pooled it
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04807764 nacompletednot on this mapstarted 2021, after this paper: background citation

Priming With High-Frequency Trans-spinal Stimulation to Augment Locomotor Benefits in Spinal Cord Injury

TypeinterventionalSponsorCity University of New YorkRan2021 to 2024Enrolled14ConditionsSpinal Cord Injuries, Paraplegia, Spinal, Tetraplegia/Tetraparesis, Paraplegia, SpasticArmsStanding transspinal stimulation followed by robotic gait training, Lying transspinal stimulation followed by robotic gait training, Standing sham transspinal stimulation followed by robotic gait training
3 · Its place in the literature

Who cites it

97 citing papers in PubMed, 6 syntheses or guidelines pooled it, 134 citations in OpenAlex.

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37 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 5 countries.

Mrinal Rath1 Department of Biomedical Engineering, University of California , Los Angeles, California.
Albert H Vette3 Department of Mechanical Engineering, University of Alberta , Donadeo Innovation Centre for Engineering, Edmonton, Alberta, Canada .
Shyamsundar Ramasubramaniam2 Department of Integrative Biology and Physiology, University of California , Los Angeles, California.
Kun Li5 Division of Engineering and Applied Sciences, California Institute of Technology , Pasadena, California.
Joel Burdick5 Division of Engineering and Applied Sciences, California Institute of Technology , Pasadena, California.
Victor R Edgerton1 Department of Biomedical Engineering, University of California , Los Angeles, California.
Yury P Gerasimenko2 Department of Integrative Biology and Physiology, University of California , Los Angeles, California.
Dimitry G Sayenko2 Department of Integrative Biology and Physiology, University of California , Los Angeles, California.
California Institute of Technology · USUniversity of California, Los Angeles · USAlberta Health Services · CAHouston Methodist · USInstitut Guttmann · ESPavlov Institute of Physiology of the Russian Academy of Sciences · RU

Funding

A Theranostic Tool to Assess and Enable Spared Spinal Motor Function After SCIR43EB018232 · NIBIB · NEUROENABLING TECHNOLOGIES, INC. · PI EDGERTON, REGGIE, LU, DANIEL · 2013 to 2014
$692k
NIBIB NIH HHS R43 EB018232
6 · The paper itself

Abstract

Electrical neuromodulation of spinal networks improves the control of movement of the paralyzed limbs after spinal cord injury (SCI). However, the potential of noninvasive spinal stimulation to facilitate postural trunk control during sitting in humans with SCI has not been investigated. We hypothesized that transcutaneous electrical stimulation of the lumbosacral enlargement can improve trunk posture. Eight participants with non-progressive SCI at C3-T9, American Spinal Injury Association Impairment Scale (AIS) A or C, performed different motor tasks during sitting. Electromyography of the trunk muscles, three-dimensional kinematics, and force plate data were acquired. Spinal stimulation improved trunk control during sitting in all tested individuals. Stimulation resulted in elevated activity of the erector spinae, rectus abdominis, and external obliques, contributing to improved trunk control, more natural anterior pelvic tilt and lordotic curve, and greater multi-directional seated stability. During spinal stimulation, the center of pressure (COP) displacements decreased to 1.36 ± 0.98 mm compared with 4.74 ± 5.41 mm without stimulation (p = 0.0156) in quiet sitting, and the limits of stable displacement increased by 46.92 ± 35.66% (p = 0.0156), 36.92 ± 30.48% (p = 0.0156), 54.67 ± 77.99% (p = 0.0234), and 22.70 ± 26.09% (p = 0.0391) in the forward, backward, right, and left directions, respectively. During self-initiated perturbations, the correlation between anteroposterior arm velocity and the COP displacement decreased from r = 0.5821 (p = 0.0007) without to r = 0.5115 (p = 0.0039) with stimulation, indicating improved trunk stability. These data demonstrate that the spinal networks can be modulated transcutaneously with tonic electrical spinal stimulation to physiological states sufficient to generate a more stable, erect sitting posture after chronic paralysis.

Indexed as

Postural BalanceSitting PositionAdultElectric Stimulation TherapyFemaleHumansMaleMiddle AgedParalysisPostureSpinal Cord InjuriesTorsoYoung Adultneuromodulationparalysisseated posturetranscutaneous electrical spinal cord stimulationtrunk stability and control

Identifiers

PMID29786465
PMCPMC6205803
OpenAlexW2803538145

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.