Evidence map›Paper›PMID 29786139›Full record

ArticleInternational journal of cancer2019

One-carbon metabolite ratios as functional B-vitamin markers and in relation to colorectal cancer risk.

Björn Gylling, Robin Myte, Arve Ulvik, Per M Ueland, Øivind Midttun, Jörn Schneede, Göran Hallmans, Jenny Häggström, Ingegerd Johansson, Bethany Van Guelpen and 1 more

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In one paragraph

Article in International journal of cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Björn GyllingDepartment of Medical Biosciences, Pathology, Umeå University, Umeå, Sweden.
Robin MyteDepartment of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden.
Arve UlvikBevital AS, Laboratory building, Bergen, Norway.
Per M UelandDepartment of Clinical Science, University of Bergen and Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway.
Øivind MidttunBevital AS, Laboratory building, Bergen, Norway.
Jörn SchneedeDepartment of Clinical Pharmacology, Pharmacology and Clinical Neurosciences, Umeå University, Umeå, Sweden.
Göran HallmansDepartment of Public Health and Clinical Medicine, Nutritional Research, Umeå University, Umeå, Sweden.
Jenny HäggströmDepartment of Statistics, Umeå School of Business and Economics, Umeå University, Umeå, Sweden.
Ingegerd JohanssonDepartment of Odontology, Cariology, Umeå University, Umeå, Sweden.
Bethany Van GuelpenDepartment of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden.ORCID 0000-0002-9692-101X
Richard PalmqvistDepartment of Medical Biosciences, Pathology, Umeå University, Umeå, Sweden.ORCID 0000-0002-9933-2843
Umeå University · SEBevital (Norway) · NOHaukeland University Hospital · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

One-carbon metabolism biomarkers are easily measured in plasma, but analyzing them one at a time in relation to disease does not take into account the interdependence of the many factors involved. The relative dynamics of major one-carbon metabolism branches can be assessed by relating the functional B-vitamin marker total homocysteine (tHcy) to transsulfuration (total cysteine) and methylation (creatinine) outputs. We validated the ratios of tHcy to total cysteine (Hcy:Cys), tHcy to creatinine (Hcy:Cre) and tHcy to cysteine to creatinine (Hcy:Cys:Cre) as functional markers of B-vitamin status. We also calculated the associations of these ratios to colorectal cancer (CRC) risk. Furthermore, the relative contribution of potential confounders to the variance of the ratio-based B-vitamin markers was calculated by linear regression in a nested case-control study of 613 CRC cases and 1,190 matched controls. Total B-vitamin status was represented by a summary score comprising Z-standardized plasma concentrations of folate, cobalamin, betaine, pyridoxal 5'-phosphate and riboflavin. Associations with CRC risk were estimated using conditional logistic regression. We found that the ratio-based B-vitamin markers all outperformed tHcy as markers of total B-vitamin status, in both CRC cases and controls. In addition, associations with CRC risk were similar for the ratio-based B-vitamin markers and total B-vitamin status (approximately 25% lower risk for high vs. low B-vitamin status). In conclusion, ratio-based B-vitamin markers were good predictors of total B-vitamin status and displayed similar associations as total B-vitamin status with CRC risk. Since tHcy and creatinine are routinely clinically analyzed, Hcy:Cre could be easily implemented in clinical practice.

Indexed as

BetaineBiomarkers, TumorCarbonCase-Control StudiesColorectal NeoplasmsCreatinineCysteineFemaleFolic AcidHomocysteineHumansMaleMiddle AgedNutritional StatusPyridoxal PhosphateRiboflavinBetaineBiomarkers, TumorCarbonCreatinineCysteineFolic AcidHomocysteinePyridoxal PhosphateRiboflavinVitamin B 12Vitamin B Complexbiochemistrybiomarkerscolorectal cancerhomocysteine

Identifiers

PMID29786139
PMCPMC6587534
OpenAlexW2773908006

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.