ArticleNature neuroscience2018
Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety.
Open access · bronzeAbstract read
In one paragraph
Article in Nature neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed
7.1field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
72 citing papers in PubMed, 145 citations in OpenAlex.
- Adaptation of hypothalamic CRH neuron responses to stress and pup cues during motherhood.Communications biology · 2026Article
- Ketogenic Diet Promotes Reward Learning by Upregulating Hippocampal CAMK2A Expression and Activating Dopamine Synaptic Signaling.International journal of molecular sciences · 2026Article
- Chloride homeostasis dysfunction drives hyperactivation of corticotropin-releasing factor-expressing neurons in the amygdala in stress-induced hypertension.The Journal of clinical investigation · 2026Article
- Uncovering Hidden Phenotypes in NEX-Cre Mice: Behavioral and Cellular Alterations Demand Re-Evaluation of a Widely Used Transgenic Line.Journal of neurochemistry · 2026Article
- Stress History Modulates Corticotropin-Releasing Factor Neurons to Establish Resilience.Biological psychiatry global open science · 2026Article
- Corticotropin releasing hormone-expressing inputs to the thalamic paraventricular nucleus: pathways from mother to memory?Neurobiology of stress · 2026Article
- Chemogenetic modulation of CRF neurons in the BNST compensates for phenotypic behavioral differences in fear extinction learning of 5-HT2C receptor mutant mice.Translational psychiatry · 2026Article
- The bed nucleus of the stria terminalis as a neuromodulatory target for refractory epilepsy.Frontiers in network physiology · 2026Review
- Transcriptome-informed metabolic modeling reveals astrocyte-specific vulnerabilities in mild cognitive impairment and Alzheimer's disease progression.Frontiers in bioinformatics · 2026Article
- Disentangling the effects of corticotrophin releasing factor and GABA release from the bed nucleus of the stria terminalis on ethanol self-administration in mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Electroacupuncture-Medication Combined Therapy Improves Sepsis Outcomes by Regulating PVN Neuronal Activities.Current medical science · 2025Article
- Ultradian rhythms of CRHProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Thermal vests help patients with anorexia nervosa to cope with mealtime anxiety.Journal of eating disorders · 2025Article
- Amino Acid-Sensing Neurons in the Anterior Piriform Cortex Control Brown Adipose Tissue Thermogenesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Investigating the effect of Arvcf reveals an essential role on regulating the mesolimbic dopamine signaling-mediated nicotine reward.Communications biology · 2025Article
- Deep phenotyping reveals CRH and FKBP51-dependent behavioral profiles following chronic social stress exposure in male mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- From trauma to depression: structural, synaptic, epigenetic, and molecular pathways linking early stress to lifelong vulnerability.Frontiers in psychiatry · 2025Review
- Reducing stress and alcohol-related behaviors by targeting D1-CRHR1 receptor interactions in the amygdala.Frontiers in pharmacology · 2025Article
- The Hypothalamic Medial Preoptic Area-Paraventricular Nucleus Circuit Modulates Depressive-Like Behaviors in a Mouse Model of Postpartum Depression.Research (Washington, D.C.) · 2025Article
- Targeting corticotropin-releasing hormone receptor type 1 (Crhr1) neurons: validating the specificity of a novel transgenic Crhr1-FlpO mouse.Brain structure & function · 2024Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors at 5 institutions in 4 countries.
Nina DedicDepartment of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, Germany.
Claudia KühneDepartment of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, Germany.
Mira JakovcevskiDepartment of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, Germany.ORCID http://orcid.org/0000-0003-2262-823X
Jakob HartmannDepartment of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, Germany.
Andreas J GenewskyDepartment of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, Germany.ORCID http://orcid.org/0000-0002-6017-2862
Karina S GomesDepartment of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, Germany.
Elmira AnderzhanovaDepartment of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, Germany.
Max L PöhlmannDepartment of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, Germany.
Simon ChangDepartment of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, Germany.
Adam KolarzDepartment of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, Germany.
Annette M VoglDepartment of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, Germany.
Julien DineDepartment of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, Germany.
Michael W MetzgerDepartment of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, Germany.
Bianca SchmidDepartment of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, Germany.
Rafael C AlmadaDepartment of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, Germany.
Kerry J ResslerDepartment of Psychiatry, Harvard Medical School and McLean Hospital, Belmont, MA, USA.
Carsten T WotjakDepartment of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, Germany.
Valery GrinevichSchaller Research Group on Neuropeptides, German Cancer Research Center, Central Institute of Mental Health, University of Heidelberg, Heidelberg, Germany.
Alon ChenDepartment of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, Germany.ORCID http://orcid.org/0000-0003-3625-8233
Mathias V SchmidtDepartment of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, Germany.ORCID http://orcid.org/0000-0002-3788-2268
Wolfgang WurstInstitute of Developmental Genetics, Helmholtz Zentrum München, Munich, Germany.
Damian RefojoDepartment of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, Germany.
Jan M DeussingDepartment of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, Germany. deussing@psych.mpg.de.ORCID http://orcid.org/0000-0002-9329-5252
Max Planck Institute of Psychiatry · DEHarvard University · USGerman Cancer Research Center · DEMunich University of Applied Sciences · DEUniversidade Paulista · BR
Funding
SPARED CenterP50MH115874 · NIMH · MCLEAN HOSPITAL · PI RESSLER, KERRY J. · 2019 to 2023
$13.7MCell Type Specific Genomic and Functional Dissection of Fear-Off Amygdala PathwaysR01MH108665 · NIMH · MCLEAN HOSPITAL · PI BOLSHAKOV, VADIM, RESSLER, KERRY J. · 2016 to 2025
$7.5MNIMH NIH HHS P50 MH115874NIMH NIH HHS R01 MH108665
Abstract
The interplay between corticotropin-releasing hormone (CRH) and the dopaminergic system has predominantly been studied in addiction and reward, while CRH-dopamine interactions in anxiety are scarcely understood. We describe a new population of CRH-expressing, GABAergic, long-range-projecting neurons in the extended amygdala that innervate the ventral tegmental area and alter anxiety following chronic CRH depletion. These neurons are part of a distinct CRH circuit that acts anxiolytically by positively modulating dopamine release.
Indexed as
AmygdalaAnimalsAnxietyCalcium-Calmodulin-Dependent Protein Kinase Type 2Corticotropin-Releasing HormoneCRF Receptor, Type 1Dendritic SpinesDopamineGABAergic NeuronsInjectionsMaleMiceMice, KnockoutMotor ActivityOptogeneticsPain PerceptionCalcium-Calmodulin-Dependent Protein Kinase Type 2Camk2a protein, mouseCorticotropin-Releasing HormoneCRF Receptor, Type 1CRF receptor type 2DopamineReceptors, Corticotropin-Releasing Hormone
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.