ArticleChinese medical journal2018
Overall Blastocyst Quality, Trophectoderm Grade, and Inner Cell Mass Grade Predict Pregnancy Outcome in Euploid Blastocyst Transfer Cycles.
Article in Chinese medical journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Morphological parameters of the blastocyst to predict embryo quality: a systematic review and meta-analysis.Journal of assisted reproduction and genetics · 2025Pooled it
- Biosimilar recombinant follitropin alfa preparations versus the reference product (Gonal-F®) in couples undergoing assisted reproductive technology treatment: a systematic review and meta-analysis.Reproductive biology and endocrinology : RB&E · 2021Pooled it
- Evaluation of the clinical utility of poor-quality embryos using an extended in vitro embryo culture system.The Journal of reproduction and development · 2026Article
- Reduced Granulosa Cell AKT2 mRNA Expression in Women with Unexplained Infertility: A Prospective Case-Control Study of ICSI Cycles.Biomedicines · 2026Article
- Targeting Inhibin Enhances Wagyu Oocyte Competence and Embryo Quality: A Comparative Study of In Vivo Immunization and In Vitro Antibody Supplementation.Antioxidants (Basel, Switzerland) · 2026Article
- MiMics-Net: A Multimodal Interaction Network for Blastocyst Component Segmentation.Diagnostics (Basel, Switzerland) · 2026Article
- Usefulness of embryo evaluation via artificial intelligence-based image analysis.Fujita medical journal · 2026Article
- Impact of ovarian stimulation duration in GnRH antagonist protocols on the cumulative ongoing pregnancy rate in women with normal ovarian reserve: a cohort study.Reproductive biology and endocrinology : RB&E · 2026Article
- Beyond aneuploidy: embryo morphology, maternal age, and miscarriage dynamics in PGT-A selected single embryo transfer.Journal of assisted reproduction and genetics · 2026Article
- Effect of blastocyst quality on neonatal outcomes in frozen embryo transfer cycles: a cohort study.Journal of assisted reproduction and genetics · 2025Article
- Semen Characteristics and Embryo Outcomes in IVF.Journal of family & reproductive health · 2025Article
- Pregnancy and neonatal outcomes of borderline blastocysts: a novel evaluation model based on inner cell mass and trophectoderm parameters.Archives of gynecology and obstetrics · 2025Article
- Elective single blastocyst transfer can achieve acceptable clinical pregnancy and live birth rates compared with elective double cleavage-stage embryo transfer in fresh cycles.BMC pregnancy and childbirth · 2025Article
- Evaluation of the follicular fluid thiol/disulfide balance among patients with poor ovarian response.Clinical and experimental reproductive medicine · 2025Article
- The Istanbul consensus update: a revised ESHRE/ALPHA consensus on oocyte and embryo static and dynamic morphological assessment†,‡.Human reproduction (Oxford, England) · 2025Article
- Association between hatching status and pregnancy outcomes in single blastocyst transfers: a retrospective cohort analysis.Journal of assisted reproduction and genetics · 2025Article
- Effect of Bovine Follicular Fluid Small Extracellular Vesicles Isolated by Ultracentrifugation and Chromatography on In Vitro Oocyte Maturation and Embryo Development.International journal of molecular sciences · 2025Article
- Human Recombinant Interleukin-6 and Leukemia Inhibitory Factor Improve Inner Cell Mass Cell Number but Lack Cryoprotective Activities on In Vitro-Produced Bovine Blastocysts.Animals : an open access journal from MDPI · 2025Article
- Non Invasive Preimplantation Testing for Aneuploidies in Assisted Reproduction: A SWOT Analysis.Reproductive sciences (Thousand Oaks, Calif.) · 2025Review
- Effects of edible bird's nest and EDTA on cadmium toxicity exposed rats' embryo production, quality, and pre- and post-embryo transfer pregnancy rates.Journal of advanced veterinary and animal research · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite recent advances that have improved the pregnancy success rates that can be achieved via in vitro fertilization (IVF) therapy, it is not yet clear which blastocyst morphological parameters best predict the outcomes of single blastocyst transfer. In addition, most of the previous studies did not exclude the effect of embryo aneuploidy on blastocysts transfer. Thus, the present study investigated the predictive value of various parameters on the pregnancy outcomes achieved via the transfer of frozen euploid blastocysts.
methodsThe study retrospectively analyzed 914 single euploid blastocyst transfer cycles that were performed at the Peking University Third Hospital Reproductive Medical Center between June 2011 and May 2016. The expansion, trophectoderm (TE), and inner cell mass (ICM) quality of the blastocysts were assessed based on blastocyst parameters, and used to differentiate between "excellent", "good", "average", and "poor"-quality embryos. The relationship between these embryo grades and the achieved pregnancy outcomes was then analyzed via the Chi-square and logistic regression tests.
resultsFor embryo grades of excellent, good, average and poor, the clinical pregnancy rates were 65.0%, 59.3%, 50.3% and 33.3%, respectively; and the live-birth rates were 50.0%, 49.7%, 42.3% and 25.0%, respectively. Both the clinical pregnancy rate (χ
conclusionsA higher overall euploid blastocyst quality is shown to correlate most strongly with optimal pregnancy outcomes. The study thus supports the use of the described TE and ICM morphological grades to augment current embryo selection criteria.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.