Evidence map›Paper›PMID 29785842›Full record

ArticleJournal of clinical laboratory analysis2018

Circular RNA 0068669 as a new biomarker for hepatocellular carcinoma metastasis.

Ting Yao, Qingqing Chen, Zhouwei Shao, Zhihua Song, Liyun Fu, Bingxiu Xiao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical laboratory analysis, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Circular RNAs in hepatocellular carcinoma: Recent advances.World journal of gastrointestinal oncology · 2022
    Review
  9. Review
  10. Emerging roles of circular RNAs in liver cancer.JHEP reports : innovation in hepatology · 2022
    Review
  11. Review
  12. Article
  13. Review
  14. Review on circular RNAs and new insights into their roles in cancer.Computational and structural biotechnology journal · 2021
    Review
  15. Review
  16. Article
  17. Current Status of Research on the Role of Circular RNAs in Hepatocellular Carcinoma and Clinical Implications.Medical science monitor : international medical journal of experimental and clinical research · 2020
    Review
  18. Review
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ting YaoDepartment of Biochemistry and Molecular Biology, and Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo, China.
Qingqing ChenDepartment of Biochemistry and Molecular Biology, and Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo, China.
Zhouwei ShaoDepartment of Biochemistry and Molecular Biology, and Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo, China.
Zhihua SongDepartment of Biochemistry and Molecular Biology, and Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo, China.
Liyun FuNingbo No. 2 Hospital and the Affiliated Hospital, Medical School of Ningbo University, Ningbo, China.ORCID http://orcid.org/0000-0001-7025-5162
Bingxiu XiaoDepartment of Biochemistry and Molecular Biology, and Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo, China.ORCID http://orcid.org/0000-0002-8592-9251

Funding

Applied Research Project on Nonprofit Technology of Zhejiang Province 2016C33177Foundation for Hepatitis Prevention and Control Project of China TQGB20150219K. C. Wong Magna Fund in Ningbo UniversityNatural Science Foundation of Ningbo 2017A610147Scientific Innovation Team Project of Ningbo 2017C110019Social Development Major Projects of Ningbo 2016C5005Zhejiang Medical Scientific Research Foundation 2017KY140Zhejiang Medical Scientific Research Foundation 2018RC062Zhejiang Provincial High-Education Teaching Reform Project jg2015047
6 · The paper itself

Abstract

backgroundCircular RNAs (circRNAs) play important roles in disease occurrence. However, the roles of circRNAs in the diagnosis of hepatocellular carcinoma (HCC) are largely unknown. The aim of this study is to investigate the clinical diagnostic values of hsa_circ_0068669 (Alias: hsa_circ_103561), one of the representative HCC-associated circRNAs.

methodsHsa_circ_0068669 expression levels in HCC tissues, HCC cell lines, and chronic hepatitis tissues were detected by real-time quantitative reverse transcription-polymerase chain reaction. Its expression levels between HCC tissues and adjacent non-tumorous tissues were analyzed using paired t test. Independent t test and one-way analysis of variance (ANOVA) were performed to analyze the relationships between hsa_circ_0068669 expression levels and clinicopathological factors of patients with HCC. A receiver operating characteristic (ROC) curve was established to estimate the value of hsa_circ_0068669 as a biomarker in HCC.

resultsHsa_circ_0068669 expression was significantly downregulated in HCC tissues and HCC cell lines compared with paired non-tumorous tissues and normal hepatic cell line, respectively. Moreover, hsa_circ_0068669 expression in HCC tissues was decreased comparing with chronic hepatitis tissues. Furthermore, hsa_circ_0068669 expression was correlated with microvascular invasion and TNM stages.

conclusionsOur findings indicate that hsa_circ_0068669 might be served as a novel potential biomarker for HCC metastasis.

Indexed as

Biomarkers, TumorCarcinoma, HepatocellularFemaleGene Expression Regulation, NeoplasticHumansLiverLiver NeoplasmsMaleMiddle AgedRNARNA, CircularBiomarkers, TumorRNARNA, Circularbiomarkercircular RNAgene expressionhepatocellular carcinomametastasis

Identifiers

PMID29785842
PMCPMC6816935

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.