Evidence map›Paper›PMID 29785582›Full record

ArticleJournal of neurovirology2018

Altered cerebro-cerebellum resting-state functional connectivity in HIV-infected male patients.

Huijuan Wang, Ruili Li, Yawen Zhou, Yanming Wang, Jin Cui, Benedictor Alexander Nguchu, Bensheng Qiu, Xiaoxiao Wang, Hongjun Li

Abstract read
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In one paragraph

Article in Journal of neurovirology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

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  13. Synergistic effects of HIV and marijuana use on functional brain network organization.Progress in neuro-psychopharmacology & biological psychiatry · 2021
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  20. Diagnostic and prognostic biomarkers for HAND.Journal of neurovirology · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Huijuan WangCenters for Biomedical Engineering, University of Science and Technology of China, Hefei, Anhui, 230026, China.
Ruili LiDepartment of Radiology, Beijing Youan Hospital, Capital Medical University, No.8, Xi Tou Tiao, Youanmen Wai, Feng Tai District, Beijing, 10069, China.
Yawen ZhouCenters for Biomedical Engineering, University of Science and Technology of China, Hefei, Anhui, 230026, China.
Yanming WangCenters for Biomedical Engineering, University of Science and Technology of China, Hefei, Anhui, 230026, China.
Jin CuiCenters for Biomedical Engineering, University of Science and Technology of China, Hefei, Anhui, 230026, China.
Benedictor Alexander NguchuCenters for Biomedical Engineering, University of Science and Technology of China, Hefei, Anhui, 230026, China.
Bensheng QiuCenters for Biomedical Engineering, University of Science and Technology of China, Hefei, Anhui, 230026, China.
Xiaoxiao WangCenters for Biomedical Engineering, University of Science and Technology of China, Hefei, Anhui, 230026, China. wang506@ustc.edu.cn.
Hongjun LiDepartment of Radiology, Beijing Youan Hospital, Capital Medical University, No.8, Xi Tou Tiao, Youanmen Wai, Feng Tai District, Beijing, 10069, China. lihongjun00113@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In addition to the role of planning and executing movement, the cerebellum greatly contributes to cognitive process. Numerous studies have reported structural and functional abnormalities in the cerebellum for HIV-infected patients, but little is known about the altered functional connectivity of particular cerebellar subregions and the cerebrum. Therefore, this study aimed to explore the resting-state functional connectivity (rsFC) changes of the cerebellum and further analyze the relationship between the rsFC changes and the neuropsychological evaluation. The experiment involved 26 HIV-infected men with asymptomatic neurocognitive impairment (ANI) and 28 healthy controls (HC). We selected bilateral hemispheric lobule VI and lobule IX as seed regions and mapped the whole-brain rsFC for each subregion. Results revealed that right lobule VI showed significant increased rsFC with the anterior cingulate cortex (ACC) in HIV-infected subjects. In addition, the correlation analysis on HIV-infected subjects illustrated the increased rsFC was negatively correlated with the attention/working memory score. Moreover, significantly increased cerebellar rsFCs were also observed in HIV-infected patients related to right inferior frontal gyrus (IFG) and right superior medial gyrus (SMG) while decreased rsFC was just found between right lobule VI and the left hippocampus (HIP). These findings suggested that, abnormalities of cerebro-cerebellar functional connectivity might be associated with cognitive dysfunction in HIV-infected men, particularly working memory impairment. It could also be the underlying mechanism of ANI, providing further evidence for early injury in the neural substrate of HIV-infected patients.

Indexed as

AdultAIDS Dementia ComplexCerebellumCerebrumHumansMaleNeural PathwaysRestCerebellumFunctional connectivityHIVResting-state fMRI

Identifiers

PMID29785582

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.