Evidence map›Paper›PMID 29785574›Full record

ArticleDrug delivery and translational research2018

In situ nanostructured hydrogel of resveratrol for brain targeting: in vitro-in vivo characterization.

Amarjitsing Rajput, Aditi Bariya, Ahmed Allam, Sarah Othman, Shital B Butani

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Drug delivery and translational research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. A Review on Nanotechnology basedCNS & neurological disorders drug targets · 2025
    Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. Application of stimuli-responsive hydrogel in brain disease treatment.Frontiers in bioengineering and biotechnology · 2024
    Review
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Amarjitsing RajputInstitute of Pharmacy, Department of Pharmaceutics, Nirma University, S.G. Highway, Ahmedabad, Gujarat, India.
Aditi BariyaArihant School of Pharmacy and Bio-Research Institute, Gandhinagar, Gujarat, India.
Ahmed AllamDepartment of Zoology, Faculty of Science, Beni-suef University, Beni-suef, Egypt.
Sarah OthmanBiology Department, Faculty of Science, Princess Nourahbint Abdulrahman University, Riyadh, Saudi Arabia.
Shital B ButaniInstitute of Pharmacy, Department of Pharmaceutics, Nirma University, S.G. Highway, Ahmedabad, Gujarat, India. shital_26@yahoo.com.ORCID http://orcid.org/0000-0001-9461-6612

Funding

GTP REGULATORY PROTEINS IN PITUITARY-DERIVED GH3 CELLSF06TW001438 · FIC · UNIVERSITY OF COLORADO DENVER · PI COOPER, DERMOT M · 1989 to 1989
–
Deanship of Scientific Research, Princess Nourahbint Abdulrahman University RG-1438-002
6 · The paper itself

Abstract

The purpose of conducting the present research work was to develop resveratrol nanostructured in situ gel for the treatment of Alzheimer's disease. Resveratrol loaded lipid carrier was prepared by melt emulsification-probe sonication method, and the final product was evaluated for particle size (132 ± 11.90 nm), polydispersity index (0.209 ± 0.005), zeta potential (- 23 ± 3.79 mV), drug loading (9.26 ± 3.79%), and entrapment efficiency (74 ± 11.40%). Following incorporation of the resveratrol nanostructured lipid carrier in gellan gum and xanthan gum, in situ gel was formulated and characterized. The optimized in situ gel showed fivefold higher permeation across the nasal mucosa as compared to resveratrol suspension-based in situ gel. Finally, optimized in situ gel was evaluated using in vivo pharmacodynamic study by the scopolamine-induced amnesia model in rats using Morris Water Maze test. It showed significant improvement in memory function in rats treated with optimized in situ gel as compared to orally administered resveratrol suspension. The enhanced permeation across nasal mucosa and improved memory function suggest that the resveratrol nanostructured lipid carrier-based in situ gel could be an effective and promising approach for the treatment of Alzheimer's disease.

Indexed as

Administration, IntranasalAdministration, OralAlzheimer DiseaseAmnesiaAnimalsDisease Models, AnimalDrug CarriersEmulsionsHydrogelsIn Vitro TechniquesMaleNanostructuresParticle SizePolysaccharides, BacterialRatsResveratrolDrug CarriersEmulsionsgellan gumHydrogelsPolysaccharides, BacterialResveratrolScopolaminexanthan gumGellan gumIn situ gelNanostructured lipid carrierNasal routeResveratrol

Identifiers

PMID29785574

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.