Evidence map›Paper›PMID 29785533›Full record

ArticleJournal of abnormal child psychology2019

Stressful Life Events, ADHD Symptoms, and Brain Structure in Early Adolescence.

Kathryn L Humphreys, Emily L Watts, Emily L Dennis, Lucy S King, Paul M Thompson, Ian H Gotlib

Abstract read
In one paragraph

Article in Journal of abnormal child psychology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Trial
  2. Article
  3. Neighborhood risks, maternal parenting entropy, and child attention-deficit/hyperactivity disorder (ADHD) symptoms.Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kathryn L HumphreysDepartment of Psychology, Stanford University, Stanford, CA, 94305, USA. k.humphreys@stanford.edu.
Emily L WattsDepartment of Psychiatry, New York University School of Medicine, New York, NY, USA.
Emily L DennisImaging Genetics Center, Mary and Mark Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Lucy S KingDepartment of Psychology, Stanford University, Stanford, CA, 94305, USA.
Paul M ThompsonImaging Genetics Center, Mary and Mark Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Ian H GotlibDepartment of Psychology, Stanford University, Stanford, CA, 94305, USA.

Funding

Training U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1M
Psychobiological Mechanisms Underlying the Association Between Early Life Stress and Depression Across AdolescenceR37MH101495 · NIMH · STANFORD UNIVERSITY · PI IAN H GOTLIB · 2018 to 2026
$6.6M
The Effects of Early Life Stress on Neurodevelopment in Children and AdolescentsR01MH101495 · NIMH · STANFORD UNIVERSITY · PI GOTLIB, IAN H · 2013 to 2016
$2.9M
Alzheimer's disease risk analyzed using population imaging genomicsR01AG040060 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2011 to 2016
$2.5M
Predicting Brain Changes in HIV/AIDSR01NS080655 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI NAVIA, BRADFORD, THOMPSON, PAUL M · 2012 to 2015
$2.3M
Longitudinal Tracking of Traumatic Brain Injury: Advanced ConnectomicsK99NS096116 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DENNIS, EMILY LARSEN · 2016 to 2017
$176k
Telomere Length as a Mediator Between Early Life Stress and Child Health OutcomesF32MH107129 · NIMH · STANFORD UNIVERSITY · PI HUMPHREYS, KATHRYN LEIGH · 2015 to 2017
$169k
NIA NIH HHS R01 AG040060NIBIB NIH HHS U54 EB020403NIMH NIH HHS F32 MH107129NIMH NIH HHS R01 MH101495NIMH NIH HHS R37 MH101495NINDS NIH HHS K99 NS096116NINDS NIH HHS R01 NS080655
6 · The paper itself

Abstract

Despite a growing understanding that early adversity in childhood broadly affects risk for psychopathology, the contribution of stressful life events to the development of symptoms of attention-deficit/hyperactivity disorder (ADHD) is not clear. In the present study, we examined the association between number of stressful life events experienced and ADHD symptoms, assessed using the Attention Problems subscale of the Child Behavior Checklist, in a sample of 214 children (43% male) ages 9.11-13.98 years (M = 11.38, SD = 1.05). In addition, we examined whether the timing of the events (i.e., onset through age 5 years or after age 6 years) was associated with ADHD symptoms. Finally, we examined variation in brain structure to determine whether stressful life events were associated with volume in brain regions that were found to vary as a function of symptoms of ADHD. We found a small to moderate association between number of stressful life events and ADHD symptoms. Although the strength of the associations between number of events and ADHD symptoms did not differ as a function of the age of occurrence of stressful experiences, different brain regions were implicated in the association between stressors and ADHD symptoms in the two age periods during which stressful life events occurred. These findings support the hypothesis that early adversity is associated with ADHD symptoms, and provide insight into possible brain-based mediators of this association.

Indexed as

Adverse Childhood ExperiencesStress, PsychologicalAdolescentAttention Deficit Disorder with HyperactivityChildFemaleHumansMagnetic Resonance ImagingMaleTemporal LobeTime FactorsWhite MatterADHDAttention problemsEarly life stressNeural correlates

Identifiers

PMID29785533
PMCPMC6249129

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.