ArticleDermatology practical & conceptual2018
Radiotherapy for inoperable Merkel cell carcinoma: a systematic review and pooled analysis.
Article in Dermatology practical & conceptual, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Successful Treatment of Facial Merkel Cell Carcinoma Using CyberKnife Radiotherapy Alone: A Case Report.Cureus · 2023Article
- The role of radiotherapy in the updated German S2k guideline for management of Merkel cell carcinoma.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2023Article
- Distinct Radiation Responses in Virus-Positive and Virus-Negative Merkel Cell Carcinoma.The Journal of investigative dermatology · 2023Article
- Survival outcomes and epidemiology of Merkel cell carcinoma of the lower limb and hip: A Surveillance, Epidemiology, and End Results analysis 2000-2018.JAAD international · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCumulative data on radiation monotherapy for Merkel cell carcinoma (MCC) is lacking.
objectiveWe sought to synthesize all available data on treatment outcomes for radiation monotherapy for inoperable stage I-III MCC.
methodsWe performed a systematic review of the current literature. Articles published in English in the PubMed database up to July 29, 2016, were evaluated.
resultsEight case reports, 4 case series, and 6 retrospective studies, yielding 68 patients, were included in our analysis. Of the 24 stage I/II patients treated with local irradiation, 6 (25%) relapsed and 1 (4%) died from MCC. Of the 24 stage I/II patients treated with local and regional nodal irradiation, 5 (21%) relapsed and 2 (8%) died from MCC. Of the 20 stage III patients treated with local and regional nodal irradiation, 12 (60%) relapsed and 7 (35%) died from MCC.
conclusionsRadiation monotherapy appears to be a reasonable treatment modality for patients with inoperable stage I-III MCC. Further investigation with prospective studies is needed to draw definitive conclusions.
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