Evidence map›Paper›PMID 29785124›Full record

ArticleOncoTargets and therapy2018

Upregulation of circ_0066444 promotes the proliferation, invasion, and migration of gastric cancer cells.

Dawei Rong, Chaoxi Dong, Kai Fu, Hanjin Wang, Weiwei Tang, Hongyong Cao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in OncoTargets and therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Circular RNAs as important players in human gastric cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2021
    Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Role of circular RNAs in gastric cancer: Recent advances and prospects.World journal of gastrointestinal oncology · 2019
    Review
  20. Current Understanding of Circular RNAs in Gastric Cancer.Cancer management and research · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Dawei RongDepartment of General Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, People's Republic of China.
Chaoxi DongDepartment of General Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, People's Republic of China.
Kai FuDepartment of General Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, People's Republic of China.
Hanjin WangDepartment of General Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, People's Republic of China.
Weiwei TangDepartment of General Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, People's Republic of China.
Hongyong CaoDepartment of General Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, People's Republic of China.
Nanjing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCircular RNAs (circRNAs), which have closed-loop structure, are involved in the pathogenesis of human diseases including various types of carcinomas. The present study aimed to investigate the relationship between a new circular RNA named circ_0066444 and gastric cancer (GC) carcinogenesis. MATERIALS AND

methodsThe circ_0066444 levels in 106 paired gastric carcinoma tissues and related adjacent normal tissues were detected by real-time quantitative reverse-transcription polymerase chain reaction. The correlation between the expression of circ_0066444 and clinicopathological features was analyzed. The impact of circ_0066444 expression on cell proliferation, invasion, as well as migration was evaluated in vitro using knockdown expression strategies. Finally, a network of circ_0066444-targeted miRNA interactions and their corresponding mRNAs was constructed.

resultscirc_0066444 was found to be significantly upregulated in 106 GC tissues as compared with paired adjacent nontumorous tissues (

conclusionOur study indicated upregulation of circ_0066444 promotes gastric cell proliferation, invasion, and migration ability and might serve as a novel biomarker for GC.

Indexed as

diagnosesinvasionmigrationmiRNAproliferation

Identifiers

PMID29785124
PMCPMC5955026
OpenAlexW2801738307

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.