SynthesisWorld journal of gastroenterology2018
Prognostic impact of the red cell distribution width in esophageal cancer patients: A systematic review and meta-analysis.
Synthesis in World journal of gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Prognostic impact of red blood cell distribution width in pulmonary hypertension patients: A systematic review and meta-analysis.Medicine · 2020Pooled it
- Prognostic significance of red blood cell distribution width in gastrointestinal cancers: A meta-analysis.Medicine · 2020Pooled it
- The association and diagnostic value of red blood cell distribution width in colorectal cancer.Medicine · 2019Pooled it
- Relationship between red cell distribution width and prognosis of patients with osteosarcoma.Bioscience reports · 2019Trial
- The association between the red blood cell distribution width-to-albumin ratio and female infertility: A cross-sectional study.Medicine · 2026Article
- Peripheral blood cells predict the efficacy and prognosis of neoadjuvant immunotherapy combined with chemotherapy for esophageal squamous cell carcinoma.BMC cancer · 2025Article
- Circulating Tumor Microenvironment in Metastasis.Cancer research · 2025Review
- Global trends and risk factors in gastric cancer: a comprehensive analysis of the Global Burden of Disease Study 2021 and multi-omics data.International journal of medical sciences · 2025Article
- Association of preoperative red blood cell width and postoperative 30-day mortality in patients undergoing non-cardiac surgery: a retrospective cohort study using propensity-score matching.Perioperative medicine (London, England) · 2024Article
- Inflammation indices in association with periodontitis and cancer.Periodontology 2000 · 2024Review
- Red Cell Distribution Width as a Predictor of Survival in Patients with Hepatocellular Carcinoma.Medicina (Kaunas, Lithuania) · 2024Article
- Non-linear relationship between red blood cell distribution width and gastrointestinal bleeding risk in stroke patients: results from multi-center ICUs.Frontiers in neurology · 2024Article
- Red cell distribution width-a potential prognostic indicator for colorectal cancer patients after radical resection in China.Journal of gastrointestinal oncology · 2023Article
- Is red cell distribution width a prognostic factor in patients with breast cancer? A meta-analysis.Frontiers in surgery · 2023Review
- Apprising Diagnostic and Prognostic Biomarkers in Cutaneous Melanoma-Persistent Updating.Journal of personalized medicine · 2022Review
- Hemoglobin/Red Blood Cell Distribution Width Ratio in Peripheral Blood Is Positively Associated with Prognosis of Patients with Primary Hepatocellular Carcinoma.Medical science monitor : international medical journal of experimental and clinical research · 2022Article
- Red Cell Distribution Width and Mortality in Patients Undergoing Percutaneous Coronary Intervention.Biomedicines · 2021Article
- Low Hemoglobin-to-Red Cell Distribution Width Ratio Is Associated with Disease Progression and Poor Prognosis in Upper Tract Urothelial Carcinoma.Biomedicines · 2021Article
- The prognostic value of red cell distribution width (RDW), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) in radiotherapy for oropharyngeal cancer.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2021Article
- Red Cell Distribution Width as a Novel Prognostic Marker in Multiple Clinical Studies.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2020Review
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo clarify the previous discrepant conclusions, we performed a meta-analysis to evaluate the prognostic value of red cell distribution width (RDW) in esophageal cancer (EC).
methodsWe searched the PubMed, EMBASE, Web of Science and Cochrane Library databases to identify clinical studies, followed by using STATA version 12.0 for statistical analysis. Studies that met the following criteria were considered eligible: (1) Studies including EC patients who underwent radical esophagectomy; (2) studies including patients with localized disease without distant metastasis; (3) studies including patients without preoperative neoadjuvant therapy; (4) studies including patients without previous antiinflammatory therapies and with available preoperative laboratory outcomes; (5) studies reporting association between the preoperative RDW and overall survival (OS)/disease-free survival (DFS)/cancer-specific survival (CSS); and (6) studies published in English.
resultsA total of six articles, published between 2015 and 2017, fulfilled the selection criteria in the end. Statistical analysis showed that RDW was not associated with the prognosis of EC patients, irrespective of OS/CSS [hazard ratio (HR) = 1.27, 95% confidence interval (CI): 0.97-1.57,
conclusionContrary to our general understanding, this meta-analysis revealed that RDW cannot serve as an indicator of poor prognosis in patients with EC. However, it may still be a useful predictor of unfavorable prognosis using an appropriate cut-off value.
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