Evidence map›Paper›PMID 29785077›Full record

ReviewWorld journal of gastroenterology2018

Mediterranean diet and nonalcoholic fatty liver disease.

Caterina Anania, Francesco Massimo Perla, Francesca Olivero, Lucia Pacifico, Claudio Chiesa

2 registry-linked trialsOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 151 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
151citing papers in PubMed, 6 pooled it
21.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04450875 nacompletednot on this map

Efficacy of Nutritional Therapy With High Methionine Content in the Treatment of Non-alcoholic Fatty Liver: a Randomized Clinical Trial

TypeinterventionalSponsorUniversidad VeracruzanaRan2015 to 2017Enrolled121ConditionsNon-alcoholic Fatty Liver Disease (NAFLD)ArmsExperimental group (with diet)
NCT06321211 completednot on this mapstarted 2024, after this paper: background citation

Development of a Novel Asian Mediterranean Diet and Its Acceptability in Non- Alcoholic Fatty Liver Disease (NAFLD)- a Pre-intervention Study

TypeobservationalSponsorSingapore Institute of TechnologyRan2024 to 2025Enrolled30ConditionsFatty Liver, Nonalcoholic
3 · Its place in the literature

Who cites it

151 citing papers in PubMed, 6 syntheses or guidelines pooled it, 344 citations in OpenAlex.

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  18. Ferroptosis: The Demise of Cells Through Phospholipid Peroxidation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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91 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Caterina AnaniaPoliclinico Umberto I Hospital, Sapienza University of Rome, Rome 00161, Italy.
Francesco Massimo PerlaPoliclinico Umberto I Hospital, Sapienza University of Rome, Rome 00161, Italy.
Francesca OliveroPoliclinico Umberto I Hospital, Sapienza University of Rome, Rome 00161, Italy.
Lucia PacificoPoliclinico Umberto I Hospital, Sapienza University of Rome, Rome 00161, Italy.
Claudio ChiesaInstitute of Translational Pharmacology, National Research Council, Rome 00133, Italy. claudio.chiesa@ift.cnr.it.
Istituto di Farmacologia Traslazionale · ITNational Research Council · ITPoliclinico Umberto I · ITSapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nonalcoholic fatty liver disease (NAFLD) is emerging as the most common chronic liver disease, and is characterized by a wide spectrum of fat-liver disorders that can result in severe liver disease and cirrhosis. Inflammation and oxidative stress are the major risk factors involved in the pathogenesis of NAFLD. Currently, there is no consensus concerning the pharmacological treatment of NAFLD. However, lifestyle interventions based on exercise and a balanced diet for quality and quantity, are considered the cornerstone of NAFLD management. Mediterranean diet (MD), rich in polyunsaturated fats, polyphenols, vitamins and carotenoids, with their anti-inflammatory and anti-oxidant effects, has been suggested to be effective in preventing cardiovascular risk factors. In adults, MD has also been demonstrated to be efficacious in reducing the risk of metabolic syndrome. However, few studies are available on the effects of the MD in both adult and pediatric subjects with NAFLD. Thus, the aims of the present narrative review are to analyze the current clinical evidence on the impact of MD in patients with NAFLD, and to summarize the main mechanisms of action of MD components on this condition.

Indexed as

Diet, MediterraneanExerciseLife StyleAdultChildGastrointestinal MicrobiomeHumansLipid MetabolismLipidsLiverNon-alcoholic Fatty Liver DiseaseOxidative StressPatient ComplianceRisk FactorsTreatment OutcomeLipidsAdultsChildrenMediterranean dietNonalcoholic fatty liver disease

Identifiers

PMID29785077
PMCPMC5960814
OpenAlexW2803151742

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.