Evidence map›Paper›PMID 29785072›Full record

ArticleBioinformation2018

Insights from the Molecular Modelling and Docking Analysis of AIF-NLS complex to infer Nuclear Translocation of the Protein.

Akash Srivaths, Shyam Ramanathan, Seethalakshmi Sakthivel, Skm Habeeb

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioinformation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 97% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Akash SrivathsDepartment of Genetic Engineering, School of Bioengineering, SRM University, Kattankulathur, Chennai - 603203.
Shyam RamanathanDepartment of Genetic Engineering, School of Bioengineering, SRM University, Kattankulathur, Chennai - 603203.
Seethalakshmi SakthivelDepartment of Genetic Engineering, School of Bioengineering, SRM University, Kattankulathur, Chennai - 603203.
Skm HabeebDepartment of Genetic Engineering, School of Bioengineering, SRM University, Kattankulathur, Chennai - 603203.
SRM University · INSRM Institute of Science and Technology · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Apoptosis Inducing Factor protein has a dual role depending on its localization in mitochondrion (energy production) and nucleus (induces apoptosis). Cell damage transports this protein to nucleus which otherwise favors mitochondrion. The alteration of Nuclear Localisation Signal tags could aid nuclear translocation. In this study, apoptosis inducing factor protein (AIF) was conjugated with strong NLS tags and its binding affinity with Importin was studied using in silico approaches such as molecular modeling and docking. This aims to improve the docking affinity of the AIF-Importin complex thus allowing for nuclear translocation, in order to induce caspase-independent apoptosis of the cell.

Indexed as

Apoptosis Inducing Factor (Mitochondrial) 1 (AIFM1)Apoptosis Inducing Factor Protein (AIF)Mitochondrial Localization Signal (MLS)Nuclear Localization Signal (NLS)Protein - Protein Interaction & ImportinThreading

Identifiers

PMID29785072
PMCPMC5953855
OpenAlexW2794889581

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.